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Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat.
H C Champion; J A Santiago; W A Murphy; D H Coy; P J Kadowitz (Profiled Author: Hunter Champion)
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
The American journal of physiology 1997;272(1 Pt 2):R234-42.
The effects of adrenomedullin (ADM)-(22-52), a putative ADM receptor antagonist, on vasodilator responses to ADM and the structurally related peptide, calcitonin gene-related peptide (CGRP), were investigated in the hindlimb vascular bed of the cat under constant-flow conditions. ADM-(22-52) had no significant effect on hindlimb perfusion pressure when injected in doses up to 120 nmol; after administration of ADM-(22-52), vasodilator responses to ADM were unchanged, whereas vasodilator responses to CGRP were inhibited. The inhibitory effects of ADM-(22-52) on responses to CGRP were selective and reversible and were similar to the inhibitory effects of the CGRP antagonist CGRP-(8-37). Hindlimb vasodilator responses to CGRP and to ADM were increased in duration by the adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase inhibitor rolipram but were not altered by inhibitors of guanosine 3',5'-cyclic monophosphate phosphodiesterase, nitric oxide synthetase, K(+)-ATP channels, the cyclooxygenase pathway, or the adrenergic nervous system. These results demonstrate that ADM-(22-52) is a selective CGRP receptor antagonist in the hindlimb vascular bed of the cat. The present data suggest that vasodilator responses to CGRP and ADM are mediated by different receptors but that these peptides dilate the hindlimb vascular bed of the cat by a similar cAMP-dependent mechanism.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
H C Champion; W A Murphy; D H Coy; P J KadowitzThe American journal of physiology 1997;272(4 Pt 2):R1047-54.
H C Champion; D G Lambert; S M McWilliams; M K Shah; W A Murphy; D H Coy; P J KadowitzRegulatory peptides 1997;70(2-3):161-5.
H C Champion; D L Akers; J A Santiago; D G Lambert; D B McNamara; P J KadowitzMolecular and cellular biochemistry 1997;176(1-2):5-11.
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