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Short-term effects of blood pressure control and antihypertensive drug regimen on glomerular filtration rate: the African-American Study of Kidney Disease and Hypertension Pilot Study.
W D Hall; J W Kusek; K A Kirk; L J Appel; G Schulman; L Y Agodoa; R Glassock; C Grim; O S Randall; S G Massry (Profiled Author: Lawrence Appel)
National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
American journal of kidney diseases : the official journal of the National Kidney Foundation 1997;29(5):720-8.
The African-American Study of Kidney Disease and Hypertension pilot study randomized 94 nondiabetic black men and women (mean age, 53 years; 75% male) with presumed hypertensive nephrosclerosis and a baseline glomerular filtration rate (GFR) of 25 to 70 mL/min/1.73 m2 (mean, 52.3 mL/min/1.73 m2) to blood pressure control at either a low mean arterial pressure (MAP) goal of < or = 92 mm Hg or a usual MAP goal of 102 to 107 mm Hg and an antihypertensive drug regimen that included either a calcium antagonist (amlodipine), a beta-blocker (atenolol), or an angiotensin-converting enzyme (ACE) inhibitor (enalapril). After 3 months of follow-up (n = 90), the mean GFR was similar (53.0 mL/min/1.73 m2 v 53.7 mL/min/1.73 m2) to the baseline levels in participants randomized to the low MAP group (n = 44), whereas the mean GFR increased by 3.9 mL/min/1.73 m2 (P = 0.02) in participants randomized to the usual MAP group (n = 46). During the same period of time, the mean GFR increased significantly in participants randomized to the calcium channel blocker regimen (n = 28) (5.7 mL/min/ 1.73 m2; P = 0.01) but not in participants randomized to the beta-blocker regimen (n = 31) (1.7 mL/min/1.73 m2; P = 0.10) or the ACE inhibitor regimen (n = 31) (1.1 mL/min/1.73 m2; P = 0.52). Changes in GFR at 3 months were significantly different among the three treatment groups (P = 0.04). We conclude that the magnitude of short-term effects of blood pressure control and antihypertensive drug regimens on GFR should be considered when estimating sample size for clinical trials designed to evaluate the effects of these interventions on long-term changes in GFR slope.
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R D Toto; K A Kirk; J Coresh; C Jones; L Appel; J Wright; V Campese; B Olutade; L Agodoa
Evaluation of serum creatinine for estimating glomerular filtration rate in African Americans with hypertensive nephrosclerosis: results from the African-American Study of Kidney Disease and Hypertension (AASK) Pilot Study.Journal of the American Society of Nephrology : JASN 1997;8(2):279-87.
J Coresh; R D Toto; K A Kirk; P K Whelton; S Massry; C Jones; L Agodoa; F Van LenteAmerican journal of kidney diseases : the official journal of the National Kidney Foundation 1998;32(1):32-42.
Gabriel Contreras; Tom Greene; Lawrence Y Agodoa; DeAnna Cheek; George Junco; Donna Dowie; James Lash; Michael Lipkowitz; Edgar R Miller; Akinlou Ojo; et al.Hypertension 2005;46(1):44-50.
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