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Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat.
H C Champion; M A Czapla; P J Kadowitz (Profiled Author: Hunter Champion)
Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
The heptadecapeptide nociceptin, also known as Orphanin FQ, is a newly discovered endogenous ligand for the opioid-like G-protein coupled receptor, ORL1. In the present study, responses to intravenous injections of nociceptin were investigated in the systemic vascular bed of the rat. Nociceptin induced dose-related decreases in systemic arterial pressure and total peripheral resistance when injected in doses of 1-30 nmol/kg i.v.. Nociceptin decreased heart rate and in doses of 10 and 30 nmol/kg i.v., significantly decreased cardiac output. In terms of relative vasodilator activity, nociceptin was approximately 10-fold less potent than the beta-adrenergic receptor agonist isoproterenol. These data show that nociceptin has novel vasodilator activity in the systemic vascular bed of the rat.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
H C Champion; P J KadowitzLife sciences 1997;60(16):PL 241-5.
H C Champion; J E Zadina; A J Kastin; L Hackler; L J Ge; P J KadowitzPeptides 1997;18(9):1393-7.
M A Czapla; H C Champion; P J KadowitzPeptides 1997;18(6):793-5.
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