The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Mutational analysis of the P16-binding domain of cyclin-dependent kinase 4 in tumors in the head region of the pancreas.
H M Ceha; M J Clement; M M Polak; G J Offerhaus; R J Slebos (Profiled Author: G. Offerhaus)
Department of Pathology, Academic Medical Center, University of Amsterdam, The Netherlands.
Alterations in genes involved in cell cycle regulation are common in many tumor types. In pancreatic adenocarcinomas, inactivating mutations in the CDKN2 gene, encoding the cyclin-dependent kinase inhibitor p16, are frequently observed. CDKN2 mutations have also been identified in the germline of 50% of patients with hereditary melanoma. Interestingly, such patients also have an increased risk for pancreatic cancers. In melanoma-prone kindreds with CDKN2 wild-type status, a mutation in one of the targets of p16, cyclin-dependent kinase 4 (CDK4) was reported, which abolishes p16 inhibition. To test the possible involvement of CDK4 mutations in pancreatic carcinoma, we analyzed sequence alterations in the p16-binding domain of CDK4 in DNA isolated from 32 tumors in the head region of the pancreas. Alterations in the CDK4 region between codon 1 and codon 56 were not observed in any of the tumors. Our results do not support disruption of the p16 pathway through CDK4 mutation as an oncogenic mechanism in pancreatic head tumorigenesis.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
R E Wilentz; C H Chung; P D Sturm; A Musler; T A Sohn; G J Offerhaus; C J Yeo; R H Hruban; R J SlebosCancer 1998;82(1):96-103.
C H Chung; R E Wilentz; M M Polak; T B Ramsoekh; L A Noorduyn; D J Gouma; K Huibregtse; G J Offerhaus; R J SlebosJournal of clinical pathology 1996;49(6):460-4.
Steven R Hustinx; Ralph H Hruban; Lorenzo M Leoni; Christine Iacobuzio-Donahue; John L Cameron; Charles J Yeo; Priscilla N Brown; Pedram Argani; Raheela Ashfaq; Noriyoshi Fukushima; et al.Cancer biology & therapy 2005;4(1):83-6.
Appears in this Publication
Author of this Publication