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Curt Civin

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Biology of CD34+CD38- cells in lymphohematopoiesis.

E M Novelli; M Ramirez; C I Civin (Profiled Author: Curt Civin)

Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. novelenm @ welchlink.welch.jhu.edu
Leukemia & lymphoma 1998;31(3-4):285-93.

Abstract

Since the discovery of the CD34 stem/progenitor cell antigen, considerable progress has been made in further purifying human lymphohematopoietic stem cells (HSC). These studies have identified a number of antigens which can be targeted to subfractionate the CD34+ cell population. In particular, several lines of evidence suggest that the rare CD38(-)subpopulation of CD34+ cells may be enriched in HSC. This review briefly summarizes relevant knowledge concerning the CD38 molecule and the results of in vitro and in vivo studies of CD34+38(-)cells. Possible clinical uses for purified CD34+38(-)cells are outlined.

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