Mary C McKenna

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TESTOSTERONE CONTROL OF PROSTATE CITRATE PRODUCTION

Renty Franklin

1 July 1981 - 31 March 1986
NAT INST OF ARTHRITIS, DIABETES, DIGESTIVE & KIDNEY DISEASES

Citrate accumulation and secretion are primary functions of the prostate glandular epithelium. This function is regulated by testosterone. This relationship is common to human prostate and rat ventral prostate. The latter serves as the experimental model to investigate the metabolic relationships which account for this unique function of prostate as well as the mechanism(s) of action of testosterone. These basic relationships must be elucidated in order to understand the pathological implications in prostate; especially since alterations in citrate production are associated with benign prostatic hypertrophy and with carcinoma of prostate in humans. Furthermore the mechanism of androgenic control of metabolic and related physiological function needs to be understood. This program will continue to elucidate the mechanism by which testosterone regulates mitochondrial aspartate aminotransferase activity which is a specific target for androgenic regulation of prostate citrate production. In addition we will elucidate the two-carbon source of citrate production and then determine the effect of testosterone on this pathway. Ultimately, the question of the total six-carbon precursors of citrate production and secretion and the key mechanisms by which this is regulated by testosterone will be resolved. Once the mechanism of action of testosterone and the metabolic relationships of citrate production have been established in the experimental model, studies of these relationships in human prostate will be feasible.

5 Resulting Publications

• 1.

  1986

  R B Franklin; M W Kahng; V Akuffo; L C Costello

  The effect of testosterone on citrate synthesis and citrate oxidation and a proposed mechanism for regulation of net citrate production in prostate.

  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme 1986;18(3):177-81.

• 2.

  1984

  R B Franklin; L C Costello

  Glutamate dehydrogenase and a proposed glutamate-aspartate pathway for citrate synthesis in rat ventral prostate.

  The Journal of urology 1984;132(6):1239-43.

• 3.

  1984

  R B Franklin; M A Khan; L C Costello

  Testosterone stimulation of mitochondrial aspartate aminotransferase in organ cultures of rat ventral prostate.

  Journal of steroid biochemistry 1984;20(3):709-13.

• 4.

  1982

  R B Franklin; R L Brandly; L C Costello

  Mitochondrial aspartate aminotransferase and the effect of testosterone on citrate production in rat ventral prostate.

  The Journal of urology 1982;127(4):798-802.

• 5.

  1982

  R B Franklin; R L Brandly; L C Costello

  Effect of inhibitors of RNA and protein synthesis on mitochondrial aspartate aminotransferase response to testosterone in rat ventral prostate.

  The Prostate 1982;3(6):637-42.

Scientific Context

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