Marcela F Pasetti

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Immune Mechanisms of Protection in S Typhi Vaccines

Marcelo B Sztein

1 September 1994 - 30 November 2011
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

36 Resulting Publications

• 1.

  2013

  Monica A McArthur; Marcelo B Sztein

  Unexpected heterogeneity of multifunctional T cells in response to superantigen stimulation in humans.

  Clinical immunology (Orlando, Fla.) 2013;146(2):140-52.

• 2.

  2012

  Rezwanul Wahid; Raphael Simon; Shah J Zafar; Myron M Levine; Marcelo B Sztein

  Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans.

  Clinical and vaccine immunology : CVI 2012;19(6):825-34.

• 3.

  2012

  Monica A McArthur; Marcelo B Sztein

  Heterogeneity of multifunctional IL-17A producing S. Typhi-specific CD8+ T cells in volunteers following Ty21a typhoid immunization.

  PloS one 2012;7(6):e38408.

• 4.

  2011

  Rosangela Salerno-Goncalves; Alessio Fasano; Marcelo B Sztein

  Engineering of a multicellular organotypic model of the human intestinal mucosa.

  Gastroenterology 2011;141(2):e18-20.

• 5.

  2011

  Rezwanul Wahid; Marcela F Pasetti; Milton Maciel; Jakub K Simon; Carol O Tacket; Myron M Levine; Marcelo B Sztein

  Oral priming with Salmonella Typhi vaccine strain CVD 909 followed by parenteral boost with the S. Typhi Vi capsular polysaccharide vaccine induces CD27+IgD-S. Typhi-specific IgA and IgG B memory cells in humans.

  Clinical immunology (Orlando, Fla.) 2011;138(2):187-200.

• 6.

  2011

  Marcela F Pasetti; Jakub K Simon; Marcelo B Sztein; Myron M Levine

  Immunology of gut mucosal vaccines.

  Immunological reviews 2011;239(1):125-48.

• 7.

  2010

  Rosângela Salerno-Goncalves; Rezwanul Wahid; Marcelo B Sztein

  Ex Vivo kinetics of early and long-term multifunctional human leukocyte antigen E-specific CD8+ cells in volunteers immunized with the Ty21a typhoid vaccine.

  Clinical and vaccine immunology : CVI 2010;17(9):1305-14.

• 8.

  2009

  James E Galen; Marcela F Pasetti; Sharon Tennant; Patricia Ruiz-Olvera; Marcelo B Sztein; Myron M Levine

  Salmonella enterica serovar Typhi live vector vaccines finally come of age.

  Immunology and cell biology 2009;87(5):400-12.

• 9.

  2009

  Wilbur H Chen; Bernard F Kozlovsky; Rita B Effros; Beatrix Grubeck-Loebenstein; Robert Edelman; Marcelo B Sztein

  Vaccination in the elderly: an immunological perspective.

  Trends in immunology 2009;30(7):351-9.

• 10.

  2009

  Rosângela Salerno-Goncalves; Marcelo B Sztein

  Priming of Salmonella enterica serovar typhi-specific CD8(+) T cells by suicide dendritic cell cross-presentation in humans.

  PloS one 2009;4(6):e5879.

• 11.

  2008

  R Wahid; R Salerno-Gonçalves; C O Tacket; M M Levine; M B Sztein

  Generation of specific effector and memory T cells with gut- and secondary lymphoid tissue- homing potential by oral attenuated CVD 909 typhoid vaccine in humans.

  Mucosal immunology 2008;1(5):389-98.

• 12.

  2007

  Marcelo B Sztein

  Cell-mediated immunity and antibody responses elicited by attenuated Salmonella enterica Serovar Typhi strains used as live oral vaccines in humans.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45 Suppl 1():S15-9.

• 13.

  2007

  Rezwanul Wahid; Rosangela Salerno-Gonçalves; Carol O Tacket; Myron M Levine; Marcelo B Sztein

  Cell-mediated immune responses in humans after immunization with one or two doses of oral live attenuated typhoid vaccine CVD 909.

  Vaccine 2007;25(8):1416-25.

• 14.

  2006

  Rosangela Salerno-Gonçalves; Marcelo B Sztein

  Cell-mediated immunity and the challenges for vaccine development.

  Trends in microbiology 2006;14(12):536-42.

• 15.

  2005

  Rosângela Salerno-Gonçalves; Rezwanul Wahid; Marcelo B Sztein

  Immunization of volunteers with Salmonella enterica serovar Typhi strain Ty21a elicits the oligoclonal expansion of CD8+ T cells with predominant Vbeta repertoires.

  Infection and immunity 2005;73(6):3521-30.

• 16.

  2004

  Rosângela Salerno-Gonçalves; Marcelo Fernandez-Viña; David M Lewinsohn; Marcelo B Sztein

  Identification of a human HLA-E-restricted CD8+ T cell subset in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine.

  Journal of immunology (Baltimore, Md. : 1950) 2004;173(9):5852-62.

• 17.

  2004

  Carol O Tacket; Marcela F Pasetti; Marcelo B Sztein; Sofie Livio; Myron M Levine

  Immune responses to an oral typhoid vaccine strain that is modified to constitutively express Vi capsular polysaccharide.

  The Journal of infectious diseases 2004;190(3):565-70.

• 18.

  2003

  Rosângela Salerno-Gonçalves; Timothy L Wyant; Marcela F Pasetti; Marcelo Fernandez-Viña; Carol O Tacket; Myron M Levine; Marcelo B Sztein

  Concomitant induction of CD4+ and CD8+ T cell responses in volunteers immunized with Salmonella enterica serovar typhi strain CVD 908-htrA.

  Journal of immunology (Baltimore, Md. : 1950) 2003;170(5):2734-41.

• 19.

  2003

  Claudia D Rosenkranz; Damasia Chiara; Caroline Agorio; Adriana Baz; Marcela F Pasetti; Fernanda Schreiber; Silvia Dematteis; Miguel Martinez; Marcelo B Sztein; Jose A Chabalgoity

  Towards new immunotherapies: targeting recombinant cytokines to the immune system using live attenuated Salmonella.

  Vaccine 2003;21(7-8):798-801.

• 20.

  2003

  Marcela F Pasetti; Myron M Levine; Marcelo B Sztein

  Animal models paving the way for clinical trials of attenuated Salmonella enterica serovar Typhi live oral vaccines and live vectors.

  Vaccine 2003;21(5-6):401-18.

• 21.

  2002

  Rosângela Salerno-Goncalves; Marcela F Pasetti; Marcelo B Sztein

  Characterization of CD8(+) effector T cell responses in volunteers immunized with Salmonella enterica serovar Typhi strain Ty21a typhoid vaccine.

  Journal of immunology (Baltimore, Md. : 1950) 2002;169(4):2196-203.

• 22.

  2002

  Marcela F Pasetti; Rosangela Salerno-Gonçalves; Marcelo B Sztein

  Salmonella enterica serovar Typhi live vector vaccines delivered intranasally elicit regional and systemic specific CD8+ major histocompatibility class I-restricted cytotoxic T lymphocytes.

  Infection and immunity 2002;70(8):4009-18.

• 23.

  2001

  M M Levine; C O Tacket; M B Sztein

  Host-Salmonella interaction: human trials.

  Microbes and infection / Institut Pasteur 2001;3(14-15):1271-9.

• 24.

  2001

  J Y Wang; M F Pasetti; F R Noriega; R J Anderson; S S Wasserman; J E Galen; M B Sztein; M M Levine

  Construction, genotypic and phenotypic characterization, and immunogenicity of attenuated DeltaguaBA Salmonella enterica serovar Typhi strain CVD 915.

  Infection and immunity 2001;69(8):4734-41.

• 25.

  2000

  C O Tacket; J Galen; M B Sztein; G Losonsky; T L Wyant; J Nataro; S S Wasserman; R Edelman; S Chatfield; G Dougan; et al.

  Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C.

  Clinical immunology (Orlando, Fla.) 2000;97(2):146-53.

• 26.

  2000

  S Wu; M Beier; M B Sztein; J Galen; T Pickett; A A Holder; O G Gómez-Duarte; M M Levine

  Construction and immunogenicity in mice of attenuated Salmonella typhi expressing Plasmodium falciparum merozoite surface protein 1 (MSP-1) fused to tetanus toxin fragment C.

  Journal of biotechnology 2000;83(1-2):125-35.

• 27.

  2000

  M F Pasetti; T E Pickett; M M Levine; M B Sztein

  A comparison of immunogenicity and in vivo distribution of Salmonella enterica serovar Typhi and Typhimurium live vector vaccines delivered by mucosal routes in the murine model.

  Vaccine 2000;18(28):3208-13.

• 28.

  2000

  C O Tacket; M B Sztein; S S Wasserman; G Losonsky; K L Kotloff; T L Wyant; J P Nataro; R Edelman; J Perry; P Bedford; et al.

  Phase 2 clinical trial of attenuated Salmonella enterica serovar typhi oral live vector vaccine CVD 908-htrA in U.S. volunteers.

  Infection and immunity 2000;68(3):1196-201.

• 29.

  2000

  T E Pickett; M F Pasetti; J E Galen; M B Sztein; M M Levine

  In vivo characterization of the murine intranasal model for assessing the immunogenicity of attenuated Salmonella enterica serovar Typhi strains as live mucosal vaccines and as live vectors.

  Infection and immunity 2000;68(1):205-13.

• 30.

  1999

  T L Wyant; M K Tanner; M B Sztein

  Salmonella typhi flagella are potent inducers of proinflammatory cytokine secretion by human monocytes.

  Infection and immunity 1999;67(7):3619-24.

• 31.

  1999

  M F Pasetti; R J Anderson; F R Noriega; M M Levine; M B Sztein

  Attenuated deltaguaBA Salmonella typhi vaccine strain CVD 915 as a live vector utilizing prokaryotic or eukaryotic expression systems to deliver foreign antigens and elicit immune responses.

  Clinical immunology (Orlando, Fla.) 1999;92(1):76-89.

• 32.

  1999

  T L Wyant; M K Tanner; M B Sztein

  Potent immunoregulatory effects of Salmonella typhi flagella on antigenic stimulation of human peripheral blood mononuclear cells.

  Infection and immunity 1999;67(3):1338-46.

• 33.

  1997

  C O Tacket; M B Sztein; G A Losonsky; S S Wasserman; J P Nataro; R Edelman; D Pickard; G Dougan; S N Chatfield; M M Levine

  Safety of live oral Salmonella typhi vaccine strains with deletions in htrA and aroC aroD and immune response in humans.

  Infection and immunity 1997;65(2):452-6.

• 34.

  1996

  K L Kotloff; F Noriega; G A Losonsky; M B Sztein; S S Wasserman; J P Nataro; M M Levine

  Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG.

  Infection and immunity 1996;64(11):4542-8.

• 35.

  1996

  F Kierszenbaum; H M Lopez; M B Sztein

  Trypanosoma cruzi downregulates the production of interleukin-2, interferon-gamma, interleukin-4 and interleukin-5 by activated human lymphocytes.

  The Journal of parasitology 1996;82(4):652-6.

• 36.

  1995

  M B Sztein; M K Tanner; Y Polotsky; J M Orenstein; M M Levine

  Cytotoxic T lymphocytes after oral immunization with attenuated vaccine strains of Salmonella typhi in humans.

  Journal of immunology (Baltimore, Md. : 1950) 1995;155(8):3987-93.

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