Kirsten E Lyke

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Malaria Research Training in Mali

29 September 2000 - 31 July 2016
FOGARTY INTERNATIONAL CENTER

DESCRIPTION (provided by applicant): This is a competitive renewal application from the University of Maryland and the University of Bamako, Mali for continued support for a successful Global Infectious Diseases Research Training Program (GIDRTP), Malaria Research Training in Mali. The overall goal of the program is to build sustainable research capacity at the Malaria Research and Training Center (MRTC) at the University of Bamako, Mali. This will be accomplished by continuing to provide malaria research training to junior and now mid-career scientists at the MRTC, filling identified gaps in expertise and capacity at the MRTC, and strengthening the sustainability of malaria research in Mali by developing the ability of MRTC scientists to compete for external research funding. The ultimate result of this training will be to benefit the public health of Mali by strengthening the country's capacity to conduct relevant biomedical research and translate the results of this research into public health tools and policies. The University of Maryland and the University of Bamako have worked in close partnership for 15 years on studies of malaria drug resistance, pathogenesis, immunity, epidemiology, genetics and clinical trials of vaccines and drugs. Since 2005, the scientific core of this collaboration has been provided by an International Collaborations in Infectious Disease Research (ICIDR) grant from NIAID to the University of Maryland and University of Bamako. This successful research partnership has helped create a rich environment for training Malian malaria researchers. The GIDRTP has provided opportunities for dozens of MRTC scientists, including short-term training in the U.S., Europe and Mali, and long-term degree training based both in Mali and in the U.S. The most senior and accomplished of the original Malaria Training Grant trainees has assumed the role of Major Foreign Collaborator on the ICIDR and Mali Program Director on this completing renewal application, providing direct evidence of the training grant's effectiveness. We propose to maintain and extend this successful training program, strengthening a bioinformatics component emphasizing applied human and parasite genomics, genomic epidemiology and evolutionary genetics research. To meet the needs of the MRTC to develop in-house expertise in these fields, including the ability to manage and analyze genomic-scale datasets, one MRTC researcher will undertake PhD training in evolutionary genetics at the University of Pennsylvania Department of Genetics and one in the University of Maryland's Molecular Epidemiology Track in the Department of Epidemiology and Public Health. PUBLIC HEALTH RELEVANCE: The overall goal of our research training program is to build sustainable malaria research capacity at the Malaria Research and Training Center (MRTC) at the University of Bamako, Mali. This will be accomplished by continuing to provide training in malaria research to junior and mid-career scientists at the MRTC, filling identified gaps in expertise and capacity at the MRTC, and strengthening the sustainability of malaria research in Mali by developing the ability of MRTC scientists to compete for external research funding. The ultimate result of this training will be to benefit the public health of Mali by strengthening the country's capacity to conduct relevant biomedical research and translate the results of this research into public health tools and policies.

15 Resulting Publications

• 1.

  2013

  Amed Ouattara; Shannon Takala-Harrison; Mahamadou A Thera; Drissa Coulibaly; Amadou Niangaly; Renion Saye; Youssouf Tolo; Sheetij Dutta; D Gray Heppner; Lorraine Soisson; et al.

  Molecular basis of allele-specific efficacy of a blood-stage malaria vaccine: vaccine development implications.

  The Journal of infectious diseases 2013;207(3):511-9.

• 2.

  2012

  Kavita Gandhi; Mahamadou A Thera; Drissa Coulibaly; Karim Traoré; Ando B Guindo; Ogobara K Doumbo; Shannon Takala-Harrison; Christopher V Plowe

  Next generation sequencing to detect variation in the Plasmodium falciparum circumsporozoite protein.

  The American journal of tropical medicine and hygiene 2012;86(5):775-81.

• 3.

  2012

  Mahamadou A Thera; Christopher V Plowe

  Vaccines for malaria: how close are we?

  Annual review of medicine 2012;63():345-57.

• 4.

  2011

  Mahamadou A Thera; Ogobara K Doumbo; Drissa Coulibaly; Matthew B Laurens; Amed Ouattara; Abdoulaye K Kone; Ando B Guindo; Karim Traore; Idrissa Traore; Bourema Kouriba; et al.

  A field trial to assess a blood-stage malaria vaccine.

  The New England journal of medicine 2011;365(11):1004-13.

• 5.

  2010

  Mahamadou A Thera; Ogobara K Doumbo; Drissa Coulibaly; Matthew B Laurens; Abdoulaye K Kone; Ando B Guindo; Karim Traore; Mady Sissoko; Dapa A Diallo; Issa Diarra; et al.

  Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.

  PloS one 2010;5(2):e9041.

• 6.

  2009

  Ogobara K Doumbo; Mahamadou A Thera; Abdoulaye K Koné; Ahmed Raza; Louisa J Tempest; Kirsten E Lyke; Christopher V Plowe; J Alexandra Rowe

  High levels of Plasmodium falciparum rosetting in all clinical forms of severe malaria in African children.

  The American journal of tropical medicine and hygiene 2009;81(6):987-93.

• 7.

  2009

  S L Takala; C V Plowe

  Genetic diversity and malaria vaccine design, testing and efficacy: preventing and overcoming 'vaccine resistant malaria'.

  Parasite immunology 2009;31(9):560-73.

• 8.

  2009

  Christopher V Plowe

  The evolution of drug-resistant malaria.

  Transactions of the Royal Society of Tropical Medicine and Hygiene 2009;103 Suppl 1():S11-4.

• 9.

  2008

  Mahamadou A Thera; Ogobara K Doumbo; Drissa Coulibaly; Dapa A Diallo; Abdoulaye K Kone; Ando B Guindo; Karim Traore; Alassane Dicko; Issaka Sagara; Mahamadou S Sissoko; et al.

  Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial.

  PloS one 2008;3(1):e1465.

• 10.

  2007

  J Alexandra Rowe; Ian G Handel; Mahamadou A Thera; Anne-Marie Deans; Kirsten E Lyke; Abdoulaye Koné; Dapa A Diallo; Ahmed Raza; Oscar Kai; Kevin Marsh; et al.

  Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting.

  Proceedings of the National Academy of Sciences of the United States of America 2007;104(44):17471-6.

• 11.

  2007

  Shannon L Takala; Drissa Coulibaly; Mahamadou A Thera; Alassane Dicko; David L Smith; Ando B Guindo; Abdoulaye K Kone; Karim Traore; Amed Ouattara; Abdoulaye A Djimde; et al.

  Dynamics of polymorphism in a malaria vaccine antigen at a vaccine-testing site in Mali.

  PLoS medicine 2007;4(3):e93.

• 12.

  2006

  Helen M Kyriacou; Graham N Stone; Richard J Challis; Ahmed Raza; Kirsten E Lyke; Mahamadou A Thera; Abdoulaye K Koné; Ogobara K Doumbo; Christopher V Plowe; J Alexandra Rowe

  Differential var gene transcription in Plasmodium falciparum isolates from patients with cerebral malaria compared to hyperparasitaemia.

  Molecular and biochemical parasitology 2006;150(2):211-8.

• 13.

  2006

  Kirsten E Lyke; Abdoulaye Dabo; Lansana Sangare; Charles Arama; Modibo Daou; Issa Diarra; Christopher V Plowe; Ogobara K Doumbo; Marcelo B Sztein

  Effects of concomitant Schistosoma haematobium infection on the serum cytokine levels elicited by acute Plasmodium falciparum malaria infection in Malian children.

  Infection and immunity 2006;74(10):5718-24.

• 14.

  2006

  Yacouba Cissoko; Modibo Daou; Kirsten E Lyke; Alassane Dicko; Issa Diarra; Abdoulaye Kone; Ando Guindo; Karim Traore; Gowdahalli Krishnegowda; Dapa A Diallo; et al.

  Serum antibody levels to glycosylphosphatidylinositols in specimens derived from matched Malian children with severe or uncomplicated Plasmodium falciparum malaria and healthy controls.

  The American journal of tropical medicine and hygiene 2006;75(2):199-204.

• 15.

  2005

  Mahamadou A Thera; Paul S Sehdev; Drissa Coulibaly; Karim Traore; Mamane N Garba; Yacouba Cissoko; Abdoulaye Kone; Ando Guindo; Alassane Dicko; Abdoul H Beavogui; et al.

  Impact of trimethoprim-sulfamethoxazole prophylaxis on falciparum malaria infection and disease.

  The Journal of infectious diseases 2005;192(10):1823-9.

Scientific Context

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