Grant Detail

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Middle Atlantic Regional Center for Excellence for Biodefense and Emerging Infect

4 September 2003 - 28 February 2014
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

55 Resulting Publications

• 1.

  2012

  Mark E Marohn; Araceli E Santiago; Kari Ann Shirey; Michael Lipsky; Stefanie N Vogel; Eileen M Barry

  Members of the Francisella tularensis phagosomal transporter subfamily of major facilitator superfamily transporters are critical for pathogenesis.

  Infection and immunity 2012;80(7):2390-401.

• 2.

  2012

  Padmaja Gade; Girish Ramachandran; Uday B Maachani; Mark A Rizzo; Tetsuya Okada; Ron Prywes; Alan S Cross; Kazutoshi Mori; Dhananjaya V Kalvakolanu

  An IFN-γ-stimulated ATF6-C/EBP-β-signaling pathway critical for the expression of Death Associated Protein Kinase 1 and induction of autophagy.

  Proceedings of the National Academy of Sciences of the United States of America 2012;109(26):10316-21.

• 3.

  2012

  Rezwanul Wahid; Raphael Simon; Shah J Zafar; Myron M Levine; Marcelo B Sztein

  Live oral typhoid vaccine Ty21a induces cross-reactive humoral immune responses against Salmonella enterica serovar Paratyphi A and S. Paratyphi B in humans.

  Clinical and vaccine immunology : CVI 2012;19(6):825-34.

• 4.

  2012

  Raphael Simon; Myron M Levine

  Glycoconjugate vaccine strategies for protection against invasive Salmonella infections.

  Human vaccines & immunotherapeutics 2012;8(4):494-8.

• 5.

  2011

  Tao Wu; Christen Grassel; Myron M Levine; Eileen M Barry

  Live attenuated Shigella dysenteriae type 1 vaccine strains overexpressing shiga toxin B subunit.

  Infection and immunity 2011;79(12):4912-22.

• 6.

  2011

  James E Galen; Raphael Simon; Robert K Ernst

  Salmonella expressing detoxified lipopolysaccharide is immunogenic and protective both as an attenuated vaccine and for delivery of foreign antigens.

  Expert review of vaccines 2011;10(12):1679-82.

• 7.

  2011

  Orit Gat; James E Galen; Sharon Tennant; Raphael Simon; William C Blackwelder; David J Silverman; Marcela F Pasetti; Myron M Levine

  Cell-associated flagella enhance the protection conferred by mucosally-administered attenuated Salmonella Paratyphi A vaccines.

  PLoS neglected tropical diseases 2011;5(11):e1373.

• 8.

  2011

  Raphael Simon; Sharon M Tennant; Jin Y Wang; Patrick J Schmidlein; Andrew Lees; Robert K Ernst; Marcela F Pasetti; James E Galen; Myron M Levine

  Salmonella enterica serovar enteritidis core O polysaccharide conjugated to H:g,m flagellin as a candidate vaccine for protection against invasive infection with S. enteritidis.

  Infection and immunity 2011;79(10):4240-9.

• 9.

  2011

  Sharon M Tennant; Jin-Yuan Wang; James E Galen; Raphael Simon; Marcela F Pasetti; Orit Gat; Myron M Levine

  Engineering and preclinical evaluation of attenuated nontyphoidal Salmonella strains serving as live oral vaccines and as reagent strains.

  Infection and immunity 2011;79(10):4175-85.

• 10.

  2011

  Satoshi Ohtake; Russell A Martin; Atul Saxena; David Lechuga-Ballesteros; Araceli E Santiago; Eileen M Barry; Vu Truong-Le

  Formulation and stabilization of Francisella tularensis live vaccine strain.

  Journal of pharmaceutical sciences 2011;100(8):3076-87.

• 11.

  2011

  Raphael Simon; Sharon M Tennant; James E Galen; Myron M Levine

  Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge.

  Vaccine 2011;29(32):5094-106.

• 12.

  2011

  I-Jane Chen; Ian M White

  High-sensitivity electrochemical enzyme-linked assay on a microfluidic interdigitated microelectrode.

  Biosensors & bioelectronics 2011;26(11):4375-81.

• 13.

  2011

  Karen E Brenneman; Mehmet Doganay; Arya Akmal; Stanley Goldman; Darrell R Galloway; Alfred J Mateczun; Alan S Cross; Leslie W Baillie

  The early humoral immune response to Bacillus anthracis toxins in patients infected with cutaneous anthrax.

  FEMS immunology and medical microbiology 2011;62(2):164-72.

• 14.

  2011

  Marcela F Pasetti; Jakub K Simon; Marcelo B Sztein; Myron M Levine

  Immunology of gut mucosal vaccines.

  Immunological reviews 2011;239(1):125-48.

• 15.

  2011

  Sharon M Tennant; Yongxia Zhang; James E Galen; Chris D Geddes; Myron M Levine

  Ultra-fast and sensitive detection of non-typhoidal Salmonella using microwave-accelerated metal-enhanced fluorescence ("MAMEF").

  PloS one 2011;6(4):e18700.

• 16.

  2011

  Douglas S Reed; Le'kneitah Smith; Tammy Dunsmore; Anita Trichel; Luis A Ortiz; Kelly Stefano Cole; Eileen Barry

  Pneumonic tularemia in rabbits resembles the human disease as illustrated by radiographic and hematological changes after infection.

  PloS one 2011;6(9):e24654.

• 17.

  2010

  Supatra Porasuphatana; Guan-Liang Cao; Pei Tsai; Fatemeh Tavakkoli; Theresa Huwar; Les Baillie; Alan S Cross; Paul Shapiro; Gerald M Rosen

  Bacillus anthracis endospores regulate ornithine decarboxylase and inducible nitric oxide synthase through ERK1/2 and p38 mitogen-activated protein kinases.

  Current microbiology 2010;61(6):567-73.

• 18.

  2010

  George W Buchman; Matthew E Cohen; Yuhong Xiao; Nicola Richardson-Harman; Peter Silvera; Louis J DeTolla; Heather L Davis; Roselyn J Eisenberg; Gary H Cohen; Stuart N Isaacs

  A protein-based smallpox vaccine protects non-human primates from a lethal monkeypox virus challenge.

  Vaccine 2010;28(40):6627-36.

• 19.

  2010

  Stephen H Gregory; Wilbur H Chen; Stephanie Mott; John E Palardy; Nicholas A Parejo; Sara Heninger; Christine A Anderson; Andrew W Artenstein; Steven M Opal; Alan S Cross

  Detoxified endotoxin vaccine (J5dLPS/OMP) protects mice against lethal respiratory challenge with Francisella tularensis SchuS4.

  Vaccine 2010;28(16):2908-15.

• 20.

  2010

  Steven T Shipley; Aruna Panda; Abdul Q Khan; Edwin H Kriel; Milton Maciel; Sofie Livio; James P Nataro; Myron M Levine; Marcelo B Sztein; Louis J DeTolla

  A challenge model for Shigella dysenteriae 1 in cynomolgus monkeys (Macaca fascicularis).

  Comparative medicine 2010;60(1):54-61.

• 21.

  2010

  Rogeria Keller; Tamara D Hilton; Hernam Rios; Edgar C Boedeker; James B Kaper

  Development of a live oral attaching and effacing Escherichia coli vaccine candidate using Vibrio cholerae CVD 103-HgR as antigen vector.

  Microbial pathogenesis 2010;48(1):1-8.

• 22.

  2010

  James E Galen; Jin Yuan Wang; Magaly Chinchilla; Christopher Vindurampulle; Jeffrey E Vogel; Haim Levy; William C Blackwelder; Marcela F Pasetti; Myron M Levine

  A new generation of stable, nonantibiotic, low-copy-number plasmids improves immune responses to foreign antigens in Salmonella enterica serovar Typhi live vectors.

  Infection and immunity 2010;78(1):337-47.

• 23.

  2010

  Sharon M Tennant; Souleymane Diallo; Haim Levy; Sofie Livio; Samba O Sow; Milagritos Tapia; Patricia I Fields; Matthew Mikoleit; Boubou Tamboura; Karen L Kotloff; et al.

  Identification by PCR of non-typhoidal Salmonella enterica serovars associated with invasive infections among febrile patients in Mali.

  PLoS neglected tropical diseases 2010;4(3):e621.

• 24.

  2009

  Eileen M Barry; Leah E Cole; Araceli E Santiago

  Vaccines against tularemia.

  Human vaccines 2009;5(12):832-8.

• 25.

  2009

  James E Galen; Marcela F Pasetti; Sharon Tennant; Patricia Ruiz-Olvera; Marcelo B Sztein; Myron M Levine

  Salmonella enterica serovar Typhi live vector vaccines finally come of age.

  Immunology and cell biology 2009;87(5):400-12.

• 26.

  2009

  K K Baker; M M Levine; J Morison; A Phillips; E M Barry

  CfaE tip mutations in enterotoxigenic Escherichia coli CFA/I fimbriae define critical human intestinal binding sites.

  Cellular microbiology 2009;11(5):742-54.

• 27.

  2009

  Araceli E Santiago; Leah E Cole; Augusto Franco; Stefanie N Vogel; Myron M Levine; Eileen M Barry

  Characterization of rationally attenuated Francisella tularensis vaccine strains that harbor deletions in the guaA and guaB genes.

  Vaccine 2009;27(18):2426-36.

• 28.

  2009

  Leah E Cole; Yang Yang; Karen L Elkins; Ellen T Fernandez; Nilofer Qureshi; Mark J Shlomchik; Leonard A Herzenberg; Leonore A Herzenberg; Stefanie N Vogel

  Antigen-specific B-1a antibodies induced by Francisella tularensis LPS provide long-term protection against F. tularensis LVS challenge.

  Proceedings of the National Academy of Sciences of the United States of America 2009;106(11):4343-8.

• 29.

  2009

  James E Galen; Magaly Chinchilla; Marcela F Pasetti; Jin Yuan Wang; Licheng Zhao; Ivonne Arciniega-Martinez; David J Silverman; Myron M Levine

  Mucosal immunization with attenuated Salmonella enterica serovar Typhi expressing protective antigen of anthrax toxin (PA83) primes monkeys for accelerated serum antibody responses to parenteral PA83 vaccine.

  The Journal of infectious diseases 2009;199(3):326-35.

• 30.

  2009

  Mahmoud Djavani; Oswald R Crasta; Yan Zhang; Juan Carlos Zapata; Bruno Sobral; Melissa G Lechner; Joseph Bryant; Harry Davis; Maria S Salvato

  Gene expression in primate liver during viral hemorrhagic fever.

  Virology journal 2009;6():20.

• 31.

  2008

  Amit R Ashtekar; Ping Zhang; Jannet Katz; Champion C S Deivanayagam; Prasad Rallabhandi; Stefanie N Vogel; Suzanne M Michalek

  TLR4-mediated activation of dendritic cells by the heat shock protein DnaK from Francisella tularensis.

  Journal of leukocyte biology 2008;84(6):1434-46.

• 32.

  2008

  Chee-Mun Fang; Jin Yuan Wang; Magaly Chinchilla; Myron M Levine; William C Blackwelder; James E Galen

  Use of mchI encoding immunity to the antimicrobial peptide microcin H47 as a plasmid selection marker in attenuated bacterial live vectors.

  Infection and immunity 2008;76(10):4422-30.

• 33.

  2008

  Julia Reis; Xiaoyu Tan; Rongjie Yang; Cheryl E Rockwell; Christopher J Papasian; Stefanie N Vogel; David C Morrison; Asaf A Qureshi; Nilofer Qureshi

  A combination of proteasome inhibitors and antibiotics prevents lethality in a septic shock model.

  Innate immunity 2008;14(5):319-29.

• 34.

  2008

  Igor S Lukashevich; Ricardo Carrion; Maria S Salvato; Keith Mansfield; Kathleen Brasky; Juan Zapata; Cristiana Cairo; Marco Goicochea; Gia E Hoosien; Anysha Ticer; et al.

  Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates.

  Vaccine 2008;26(41):5246-54.

• 35.

  2008

  Kari Ann Shirey; Leah E Cole; Achsah D Keegan; Stefanie N Vogel

  Francisella tularensis live vaccine strain induces macrophage alternative activation as a survival mechanism.

  Journal of immunology (Baltimore, Md. : 1950) 2008;181(6):4159-67.

• 36.

  2008

  Tae Jin Kang; Subhendu Basu; Lei Zhang; Karen E Thomas; Stefanie N Vogel; Les Baillie; Alan S Cross

  Bacillus anthracis spores and lethal toxin induce IL-1beta via functionally distinct signaling pathways.

  European journal of immunology 2008;38(6):1574-84.

• 37.

  2008

  Leah E Cole; Araceli Santiago; Eileen Barry; Tae Jin Kang; Kari Ann Shirey; Zachary J Roberts; Karen L Elkins; Alan S Cross; Stefanie N Vogel

  Macrophage proinflammatory response to Francisella tularensis live vaccine strain requires coordination of multiple signaling pathways.

  Journal of immunology (Baltimore, Md. : 1950) 2008;180(10):6885-91.

• 38.

  2008

  Pei Tsai; Guan-Liang Cao; Tod J Merkel; Gerald M Rosen

  Spin labelling of Bacillus anthracis endospores: a model for in vivo tracking by EPR imaging.

  Free radical research 2008;42(1):49-56.

• 39.

  2007

  Trupti N Brahmbhatt; Stephen C Darnell; Humberto M Carvalho; Patrick Sanz; Tae J Kang; Robert L Bull; Susan B Rasmussen; Alan S Cross; Alison D O'Brien

  Recombinant exosporium protein BclA of Bacillus anthracis is effective as a booster for mice primed with suboptimal amounts of protective antigen.

  Infection and immunity 2007;75(11):5240-7.

• 40.

  2007

  Darren J Perkins; Mary C Gray; Erik L Hewlett; Stefanie N Vogel

  Bordetella pertussis adenylate cyclase toxin (ACT) induces cyclooxygenase-2 (COX-2) in murine macrophages and is facilitated by ACT interaction with CD11b/CD18 (Mac-1).

  Molecular microbiology 2007;66(4):1003-15.

• 41.

  2007

  John Weaver; Tae Jin Kang; Kimberly W Raines; Guan-Liang Cao; Stephen Hibbs; Pei Tsai; Les Baillie; Gerald M Rosen; Alan S Cross

  Protective role of Bacillus anthracis exosporium in macrophage-mediated killing by nitric oxide.

  Infection and immunity 2007;75(8):3894-901.

• 42.

  2007

  Leah E Cole; Kari Ann Shirey; Eileen Barry; Araceli Santiago; Prasad Rallabhandi; Karen L Elkins; Adam C Puche; Suzanne M Michalek; Stefanie N Vogel

  Toll-like receptor 2-mediated signaling requirements for Francisella tularensis live vaccine strain infection of murine macrophages.

  Infection and immunity 2007;75(8):4127-37.

• 43.

  2007

  Mahmoud M Djavani; Oswald R Crasta; Juan Carlos Zapata; Zhangjun Fei; Otto Folkerts; Bruno Sobral; Mark Swindells; Joseph Bryant; Harry Davis; C David Pauza; et al.

  Early blood profiles of virus infection in a monkey model for Lassa fever.

  Journal of virology 2007;81(15):7960-73.

• 44.

  2007

  Alan S Cross; Frank M Calia; Robert Edelman

  From rabbits to humans: the contributions of Dr. Theodore E. Woodward to tularemia research.

  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45 Suppl 1():S61-7.

• 45.

  2007

  Myron M Levine; Karen L Kotloff; Eileen M Barry; Marcela F Pasetti; Marcelo B Sztein

  Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road.

  Nature reviews. Microbiology 2007;5(7):540-53.

• 46.

  2007

  Ricardo Carrion; Kathleen Brasky; Keith Mansfield; Curtis Johnson; Monica Gonzales; Anysha Ticer; Igor Lukashevich; Suzette Tardif; Jean Patterson

  Lassa virus infection in experimentally infected marmosets: liver pathology and immunophenotypic alterations in target tissues.

  Journal of virology 2007;81(12):6482-90.

• 47.

  2007

  Ricardo Carrion; Jean L Patterson; Curtis Johnson; Monica Gonzales; Carmen R Moreira; Anysha Ticer; Kathleen Brasky; Gene B Hubbard; Dmitry Moshkoff; Juan Zapata; et al.

  A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity.

  Vaccine 2007;25(20):4093-102.

• 48.

  2007

  Subhendu Basu; Tae Jin Kang; Wilbur H Chen; Matthew J Fenton; Les Baillie; Steve Hibbs; Alan S Cross

  Role of Bacillus anthracis spore structures in macrophage cytokine responses.

  Infection and immunity 2007;75(5):2351-8.

• 49.

  2006

  Rosangela Salerno-Gonçalves; Marcelo B Sztein

  Cell-mediated immunity and the challenges for vaccine development.

  Trends in microbiology 2006;14(12):536-42.

• 50.

  2006

  Leah E Cole; Karen L Elkins; Suzanne M Michalek; Nilofer Qureshi; Linda J Eaton; Prasad Rallabhandi; Natalia Cuesta; Stefanie N Vogel

  Immunologic consequences of Francisella tularensis live vaccine strain infection: role of the innate immune response in infection and immunity.

  Journal of immunology (Baltimore, Md. : 1950) 2006;176(11):6888-99.

• 51.

  2006

  Jannet Katz; Ping Zhang; Michael Martin; Stefanie N Vogel; Suzanne M Michalek

  Toll-like receptor 2 is required for inflammatory responses to Francisella tularensis LVS.

  Infection and immunity 2006;74(5):2809-16.

• 52.

  2006

  Kimberly W Raines; Tae Jin Kang; Stephen Hibbs; Guan-Liang Cao; John Weaver; Pei Tsai; Les Baillie; Alan S Cross; Gerald M Rosen

  Importance of nitric oxide synthase in the control of infection by Bacillus anthracis.

  Infection and immunity 2006;74(4):2268-76.

• 53.

  2005

  Tae Jin Kang; Matthew J Fenton; Matthew A Weiner; Stephen Hibbs; Subhendu Basu; Les Baillie; Alan S Cross

  Murine macrophages kill the vegetative form of Bacillus anthracis.

  Infection and immunity 2005;73(11):7495-501.

• 54.

  2005

  Les Baillie; Stephen Hibbs; Pei Tsai; Guan-Liang Cao; Gerald M Rosen

  Role of superoxide in the germination of Bacillus anthracis endospores.

  FEMS microbiology letters 2005;245(1):33-8.

• 55.

  2004

  James E Galen; Licheng Zhao; Magaly Chinchilla; Jin Yuan Wang; Marcela F Pasetti; Jeffrey Green; Myron M Levine

  Adaptation of the endogenous Salmonella enterica serovar Typhi clyA-encoded hemolysin for antigen export enhances the immunogenicity of anthrax protective antigen domain 4 expressed by the attenuated live-vector vaccine strain CVD 908-htrA.

  Infection and immunity 2004;72(12):7096-106.

Scientific Context

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