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Kevin S. McIver

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Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice.

B Limbago; K S McIver; V Penumalli; B Weinrick; J R Scott (Profiled Author: Kevin S. McIver)

Department of Microbiology and Immunology, Emory University Health Sciences Center, Atlanta, Georgia 30322, USA.
Infection and immunity 2001;69(2):1215-20.

Abstract

The Mga protein in B514Sm, a Streptococcus pyogenes strain isolated as a mouse pathogen, contains amino acid substitutions at conserved sites that render the protein defective. Replacement of mga50 with the functional homolog mga4.1 restored full expression of Mga-regulated proteins. Restoration of Mga function did not affect fibrinogen binding, nor did it affect virulence in several mouse models of group A streptococcus infection.

1 Originating Grant

Scientific Context

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