The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Restoration of Mga function to a Streptococcus pyogenes strain (M Type 50) that is virulent in mice.
B Limbago; K S McIver; V Penumalli; B Weinrick; J R Scott (Profiled Author: Kevin S. McIver)
Department of Microbiology and Immunology, Emory University Health Sciences Center, Atlanta, Georgia 30322, USA.
Infection and immunity 2001;69(2):1215-20.
The Mga protein in B514Sm, a Streptococcus pyogenes strain isolated as a mouse pathogen, contains amino acid substitutions at conserved sites that render the protein defective. Replacement of mga50 with the functional homolog mga4.1 restored full expression of Mga-regulated proteins. Restoration of Mga function did not affect fibrinogen binding, nor did it affect virulence in several mouse models of group A streptococcus infection.
1 Originating Grant
Mciver, Kevin S
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