The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
D(1) dopamine receptors potentiate nmda-mediated excitability increase in layer V prefrontal cortical pyramidal neurons.
J Wang; P O'Donnell (Profiled Author: Patricio O'Donnell)
Center for Neuropharmacology & Neuroscience, Albany Medical College, Albany, NY 12208, USA.
Cerebral cortex (New York, N.Y. : 1991) 2001;11(5):452-62.
The interactions between N-methyl-D-aspartate (NMDA) and D(1) dopamine receptors in the rat prefrontal cortex were examined using whole-cell recordings from pyramidal neurons. The effects of NMDA, the D(1) agonist SKF38393, or both compounds combined were tested on measures of cell excitability. Both NMDA (10-100 microM) and SKF38393 (5-10 microM) independently increased the number of spikes and decreased the latency of the first spike evoked by intracellular depolarizing current pulses. Combining low doses of NMDA (5 microM) and SKF38393 (2 microM) resulted in a marked increase of cell excitability. This synergism was blocked by SCH23390, protein kinase A (PKA) inhibitors, and the Ca(2+) chelator BAPTA, and reduced by nifedipine. These results indicate the presence of a dopamine- glutamate interaction in the prefrontal cortex at the postsynaptic level, by which D(1) dopamine receptors may maintain NMDA- mediated responses in prefrontal cortical pyramidal neurons through both a PKA-dependent pathway and Ca(2+)-dependent mechanisms.
1 Originating Grant
1 September 1997 - 31 May 2013
NATIONAL INSTITUTE OF MENTAL HEALTH
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