The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Fibrinogen alpha C domains contain cryptic plasminogen and tPA binding sites.
G Tsurupa; L Medved (Profiled Author: Leonid Medved)
Biochemistry Department, Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA. firstname.lastname@example.org
Annals of the New York Academy of Sciences 2001;936():328-30.
Surface plasmon resonance and ELISA experiments revealed that recombinant fibrinogen alpha C fragment (residues A alpha 221-610) corresponding to the alpha C domain binds tPA and plasminogen with high affinity. This binding was found to be Lys-dependent and occurred via independent binding sites. Study with truncated variants of the alpha C fragment located these sites in its COOH-terminal half. Binding of tPA and plasminogen to these sites stimulated activation of the latter whereas proteolytic degradation of the alpha C fragment reduced this effect substantially, suggesting the importance of the alpha C domains in regulation of fibrinolysis.
1 Originating Grant
MEDVED, LEONID V.
1 January 1998 - 31 July 2012
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
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