The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia.
K Chandrasekaran; Z Mehrabian; B Spinnewyn; K Drieu; G Fiskum (Profiled Author: Gary M Fiskum)
Department of Anesthesiology, University of Maryland School of Medicine, MSTF 5-34, 685 West Baltimore St., Baltimore, MD 21201, USA. firstname.lastname@example.org
Brain research 2001;922(2):282-92.
The neuroprotective effect of Ginkgo biloba extract (EGb 761) against ischemic injury has been demonstrated in animal models. In this study, we compared the protective effect of bilobalide, a purified terpene lactone from EGb 761, and EGb 761 against ischemic injury. We measured neuronal loss and the levels of mitochondrial DNA (mtDNA)-encoded cytochrome oxidase (COX) subunit III mRNA in vulnerable hippocampal regions of gerbils. At 7 days of reperfusion after 5 min of transient global forebrain ischemia, a significant increase in neuronal death and a significant decrease in COX III mRNA were observed in the hippocampal CA1 neurons. Oral administration of EGb 761 at 25, 50 and 100 mg/kg/day and bilobalide at 3 and 6 mg/kg/day for 7 days before ischemia progressively protected CA1 neurons from death and from ischemia-induced reductions in COX III mRNA. In addition, both bilobalide and EGb 761 protected against ischemia-induced reductions in COX III mRNA in CA1 neurons prior to their death, at 1 day of reperfusion. These results suggest that oral administration of bilobalide and EGb 761 protect against ischemia-induced neuron death and reductions in mitochondrial gene expression.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Krish Chandrasekaran; Zara Mehrabian; Brigitte Spinnewyn; Christos Chinopoulos; Katy Drieu; Gary FiskumCellular and molecular biology (Noisy-le-Grand, France) 2002;48(6):663-9.
K Chandrasekaran; Z Mehrabian; B Spinnewyn; C Chinopoulos; K Drieu; G FiskumPharmacopsychiatry 2003;36 Suppl 1():S89-94.
Flaubert Tchantchou; Pascale N Lacor; Zhiming Cao; Lixing Lao; Yan Hou; Changhai Cui; William L Klein; Yuan LuoJournal of Alzheimer's disease : JAD 2009;18(4):787-98.
Appears in this Publication
Author of this Publication