Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Clostridium difficile vaccine and serum immunoglobulin G antibody response to toxin A.

Samer Aboudola; Karen L Kotloff; Lorraine Kyne; Michel Warny; Eoin C Kelly; Stavros Sougioultzis; Paul J Giannasca; Thomas P Monath; Ciarán P Kelly (Profiled Author: Karen L Kotloff)

Gastroenterology Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Infection and immunity 2003;71(3):1608-10.

There is a strong association between serum antibody responses to toxin A and protection against Clostridium difficile diarrhea. A parenteral C. difficile toxoid vaccine induced very-high-level responses to anti-toxin A immunoglobulin G (IgG) in the sera of healthy volunteers. After vaccination, the concentrations of anti-toxin A IgG in the sera of all 30 recipients exceeded the concentrations that were associated with protection in previous clinical studies. Furthermore, the median concentration of serum anti-toxin A IgG in the test group was 50-fold higher than the previous threshold. These findings support the feasibility of using a vaccine to protect high-risk individuals against C. difficile-associated diarrhea and colitis.

15 Originating Grant

• 1.

  LEVINE, MYRON M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 2.

  Levine, Myron M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 3.

  Levine, Myron M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 4.

  LEVINE, MYRON MAX

  CONTROL MEASURES AGAINST INFECT DISEASE OTHER THAN AIDS

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 5.

  LEVINE, MYRON MAX

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 6.

  LEVINE, MYRON MAX

  CONTROL MEASURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 7.

  LEVINE, MYRON MAX

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 8.

  LEVINE, MYRON MAX

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 9.

  LEVINE, MYRON MAX

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 10.

  LEVINE, MYRON MAX

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

  30 September 1994 - 29 September 2001

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 11.

  Levine, Myron M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

• 12.

  Levine, Myron M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

• 13.

  LEVINE, MYRON M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

• 14.

  LEVINE, MYRON M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

• 15.

  LEVINE, MYRON M

  CONTROL MESURES IN AGING AND INFECTIOUS DISEASE

Scientific Context

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