The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Prognostic value of isolated troponin elevation across the spectrum of chest pain syndromes.
Sunil V Rao; E Magnus Ohman; Christopher B Granger; Paul W Armstrong; W Brian Gibler; Robert H Christenson; Vic Hasselblad; Amanda Stebbins; Steven McNulty; L Kristin Newby (Profiled Author: Robert H Christenson)
Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA. email@example.com
The American journal of cardiology 2003;91(8):936-40.
The risk of death or recurrent myocardial infarction (MI) in patients with chest pain and baseline isolated troponin elevation is unclear. To determine the early and short-term risk of death or MI associated with isolated troponin elevation across a spectrum of chest pain syndromes, we used baseline creatine kinase (CK)-MB and troponin data from the Platelet IIb/IIIa Antagonism for the Reduction of Acute Coronary Syndrome Events in a Global Organization Network (PARAGON) B troponin substudy, the Global Utilization of Strategies To Open Occluded Coronary Arteries (GUSTO) IIa troponin substudy, and the Chest Pain Evaluation by Creatine Kinase-MB, Myoglobin, and Troponin I (CHECKMATE) study. Patients were grouped into 1 of 4 categories based on marker status (troponin-positive/CK-MB-positive, troponin-positive/CK-MB-negative, troponin-negative/CK-MB-positive, or troponin-negative/CK-MB-negative). The adjusted odds of death or MI occurring at 24 hours and 30 days was assessed by baseline marker status using multivariable logistic regression, with the group negative for both markers used as the reference. Patients who were positive for both markers had the highest odds of the 24-hour and 30-day end point. The adjusted odds of the 30-day end point for patients with isolated troponin elevation were 1.3 (95% confidence interval 0.7 to 2.3) and 4.8 (95% confidence interval 1.4 to 16.0) for high- and low-risk patients, respectively. The risk for 24-hour and 30-day death or MI with isolated positive CK-MB results was lower than with isolated positive troponin results, and it was not significantly greater than if the 2 markers were negative. For patients with high- and low-risk chest pain, baseline troponin elevation without CK-MB elevation was associated with increased risk for early and short-term adverse outcomes. This suggests that these patients should be admitted to the hospital and monitored in either an intensive care or step-down unit.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
R H Christenson; L K Newby; E M OhmanMaryland medical journal (Baltimore, Md. : 1985) 1997;Suppl():18-24.
Francis M Fesmire; Robert H Christenson; Edward P Fody; Theodore A FeintuchAnnals of emergency medicine 2004;44(1):12-9.
F S Apple; R H Christenson; R Valdes; A J Andriak; A Berg; S H Duh; Y J Feng; S A Jortani; N A Johnson; B Koplen; et al.Clinical chemistry 1999;45(2):199-205.
Appears in this Publication
Author of this Publication