The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Virulence factor regulation and regulatory networks in Streptococcus pyogenes and their impact on pathogen-host interactions.
Bernd Kreikemeyer; Kevin S McIver; Andreas Podbielski (Profiled Author: Kevin S. McIver)
University Hospital Rostock, Department of Medical Microbiology and Hospital Hygiene, Schillingallee 70, 18055 Rostock, Germany. Bernd.Kreikemeyer@med.uni-rostock.de
Trends in microbiology 2003;11(5):224-32.
Streptococcus pyogenes (group A streptococcus, GAS) is a very important human pathogen with remarkable adaptation capabilities. Survival within the harsh host surroundings requires sensing potential on the bacterial side, which leads in particular to coordinately regulated virulence factor expression. GAS 'stand-alone' response regulators (RRs) and two-component signal transduction systems (TCSs) link the signals from the host environment with adaptive responses of the bacterial cell. Numerous putative regulatory systems emerged from GAS genome sequences. Only three RRs [Mga, RofA-like protein (RALP) and Rgg/RopB] and three TCSs (CsrRS/CovRS, FasBCAX and Ihk/Irr) have been studied in some detail with respect to their growth-phase-dependent activity and their influence on GAS-host cell interaction. In particular, the Mga-, RALP- and Rgg/RopB-regulated pathways display interconnected activities that appear to influence GAS colonization, persistence and spreading mechanisms, in a growth-phase-related fashion. Here, we have summarized our current knowledge about these RRs and TCSs to highlight the questions that should be addressed in future research on GAS pathogenicity.
1 Originating Grant
MCIVER, KEVIN S.
1 July 2000 - 31 January 2017
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Deborah A Ribardo; Kevin S McIverMolecular microbiology 2003;50(2):673-85.
Deborah A Ribardo; Kevin S McIverMolecular microbiology 2006;62(2):491-508.
Chadia Toukoki; Kathryn M Gold; Kevin S McIver; Zehava EichenbaumMolecular microbiology 2010;76(4):971-89.
Appears in this Publication
Author of this Publication