The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves.
Aiping Zhao; Joseph McDermott; Joseph F Urban; William Gause; Kathleen B Madden; Karla Au Yeung; Suzanne C Morris; Fred D Finkelman; Terez Shea-Donohue (Profiled Authors: Terez Shea-Donohue; Aiping M Zhao)
Nutritional Requirements and Functions Laboratory, Beltsville Human Nutrition Research Center, Agricultural Research Service, U.S. Department of Agriculture, Beltsville, MD 20705, USA.
Journal of immunology (Baltimore, Md. : 1950) 2003;171(2):948-54.
IL-4 and IL-13 promote gastrointestinal worm expulsion in part through effects on nonlymphoid cells, such as intestinal smooth muscle cells. The roles of Stat6 in IL-4-, IL-13-, and parasitic nematode-induced effects on small intestinal smooth muscle contractility were investigated in BALB/c wild-type and Stat6-deficient mice treated with a long-lasting formulation of recombinant mouse IL-4 (IL-4C) or IL-13 for 7 days. Separate groups of BALB/c mice were infected with Nippostrongylus brasiliensis or were drug-cured of an initial Heligmosomoides polygyrus infection and later reinfected. Infected mice were studied 9 and 12 days after inoculation, respectively. Segments of jejunum were suspended in an organ bath, and responses to nerve stimulation and to acetylcholine and substance P in the presence and absence of tetradotoxin, a neurotoxin, were determined. Both IL-4 and IL-13 increased smooth muscle responses to nerve stimulation in wild-type mice, but the effects were greater in IL-13-treated mice and were absent in IL-13-treated Stat6-deficient mice. Similarly, hypercontractile responses to nerve stimulation in H. polygyrus- and N. brasiliensis-infected mice were dependent in part on Stat6. IL-13, H. polygyrus, and N. brasiliensis, but not IL-4, also increased contractility to acetylcholine by mechanisms that involved Stat6 and enteric nerves. These studies demonstrate that both IL-4 and IL-13 promote intestinal smooth muscle contractility, but by different mechanisms. Differences in these effects correlate with differences in the relative importance of these cytokines in the expulsion of enteric nematode parasites.
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Aiping Zhao; Motoko Morimoto; Harry Dawson; Justin E Elfrey; Kathleen B Madden; William C Gause; Booki Min; Fred D Finkelman; Joseph F Urban; Terez Shea-DonohueJournal of immunology (Baltimore, Md. : 1950) 2005;175(4):2563-9.
Aiping Zhao; Joseph F Urban; Rex Sun; Jennifer Stiltz; Motoko Morimoto; Luigi Notari; Kathleen B Madden; Zhonghan Yang; Viktoriya Grinchuk; Thirumalai R Ramalingam; et al.Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6921-9.
Motoko Morimoto; Aiping Zhao; Rex Sun; Jennifer Stiltz; Kathleen B Madden; Margaret Mentink-Kane; Thirumalai Ramalingam; Thomas A Wynn; Joseph F Urban; Terez Shea-DonohueJournal of immunology (Baltimore, Md. : 1950) 2009;183(3):1934-9.
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