The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Immune responses to an oral typhoid vaccine strain that is modified to constitutively express Vi capsular polysaccharide.
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. email@example.com
The Journal of infectious diseases 2004;190(3):565-70.
Protection against typhoid fever might be best achieved by a vaccine that stimulates IgG antibody to Vi capsular polysaccharide (Vi) in serum, IgG antibody to O antigen in serum, and cell-mediated immune responses. Live typhoid vaccines have not elicited anti-Vi antibody, presumably because Vi expression is highly regulated. CVD 909 is an oral attenuated typhoid vaccine candidate that is engineered to constitutively express Vi. In the present study, CVD 909, at doses of 10(6-9) cfu, was orally administered to 32 healthy adults, and immune responses were measured. Although many of the volunteers generated antibody-secreting cell responses to Vi, only 2 of the 32 volunteers generated anti-Vi IgG antibody in serum.
1 Originating Grant
SZTEIN, MARCELO B.
1 September 1994 - 30 November 2011
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
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