Gary M Fiskum

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Mitochondrial mechanisms of neural cell apoptosis.

Brian M Polster; Gary Fiskum (Profiled Authors: Gary M Fiskum; Brian M Polster)

W. Harry Feinstone Department of Microbiology and Molecular Immunology, The Johns Hopkins University School of Public Health, Baltimore, Maryland, USA.
Journal of neurochemistry 2004;90(6):1281-9.

The importance of calcium overload, mitochondrial dysfunction, and free radical generation to neuropathological processes has been recognized for many years. Only more recently has evidence accumulated that the programmed cell death process of apoptosis plays an integral role not only in the development of the nervous system, but in the loss of cells following acute neurological insults and chronic disease. In 1996 came the landmark discovery that cytochrome c, an evolutionary old and essential component of the respiratory chain, has a second and deadly function when it escapes the mitochondrion: triggering the cell death cascade. A flurry of activity has since ensued in an effort to understand the mechanistic events associated with mitochondrial permeabilization during apoptosis and regulation by an enigmatic family of proteins characterized by homology to the proto-oncogene Bcl-2. This review discusses the evidence for various release mechanisms of apoptotic proteins (e.g. cytochrome c) from neural cell mitochondria, focusing particularly on roles for calcium, Bax, p53, and oxidative stress. The need for new drugs that act at the level of the mitochondrion to prevent apoptosis is also highlighted.

5 Originating Grant

• 1.

  Fiskum, Gary M

  Novel delivery of Bcl-2 for neuroprotection

  1 December 2002 - 30 November 2005

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

• 2.

  Polster, Brian M

  Regulation of anti- & pro-apoptotic functions of BAD

  1 September 2002

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

• 3.

  Zielke, H Ronald

  Metabolic & Developmental Aspects of Mental Retardation

  1 May 1997 - 31 January 2009

  NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT

• 4.

  MCKENNA, MARY C

  Metabolic &Developmental Aspects of Intellectual Disability

  1 May 1997 - 31 January 2014

  EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT

• 5.

  Fiskum, Gary

  Molecular Mechanisms of Ischemia Reperfusion Brain Injury

  1 May 1995 - 31 December 2008

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Scientific Context

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