Alice S Ryan

Publication Detail

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The metabolic syndrome in obese postmenopausal women: relationship to body composition, visceral fat, and inflammation.

Tongjian You; Alice S Ryan; Barbara J Nicklas (Profiled Author: Alice S Ryan)

Section of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA. tyou@wfubmc.edu
The Journal of clinical endocrinology and metabolism 2004;89(11):5517-22.

The purpose of this study was to investigate whether aerobic fitness, body composition, body fat distribution, and inflammation are different in obese postmenopausal women with and without the metabolic syndrome (MS), and whether the severity of MS is associated with these characteristics. Fifty-eight women (age, 59 +/- 1 yr; body mass index, 33.0 +/- 0.6 kg/m2)completed testing of maximal aerobic capacity, body composition (fat mass, lean mass, and percent body fat), body fat distribution (sc and visceral fat areas, and regional adipocyte sizes), and inflammation (C-reactive protein, IL-6, and TNF-alpha,and their soluble receptors). Lean mass (44.4 +/- 0.9 vs. 41.2 +/- 0.9 kg; P < 0.05), visceral fat area (180 +/- 10 vs. 135 +/- 7 cm2; P <0.001), and plasma soluble TNF receptor 1 (sTNFR1; 860 +/- 25 vs. 765 +/- 42 pg/ml; P < 0.05) were higher in women with the MS(n = 27) than in those without the MS (n = 31). The number of MS components was directly related to weight, body mass index, fat mass, lean mass, visceral fat area, and plasma sT-NFR1. We conclude that obese older women with the MS are characterized by high lean mass, high visceral fat, and elevated sTNFR1, and the severity of the MS is associated with body composition, visceral adiposity, and inflammation.

3 Originating Grant

• 1.

  Ryan, Alice S

  Diet and Exercise: Race, Postmenopause and Metabolism

  30 September 2001 - 31 August 2007

  NATIONAL INSTITUTE ON AGING

• 2.

  Ryan, Alice S

  OBESITY GLUCOSE METABOLISM AND DIET IN OLDER WOMEN

  1 September 1997 - 31 August 2003

  NATIONAL INSTITUTE ON AGING

• 3.

  Goldberg, Andrew P

  Claude D. Pepper Older Americans Independence Center (O*

  15 July 1994 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

Scientific Context

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