The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Selective targeting of antitumor immune responses with engineered live-attenuated Listeria monocytogenes.
Kiyoshi Yoshimura; Ajay Jain; Heather E Allen; Lindsay S Laird; Christina Y Chia; Sowmya Ravi; Dirk G Brockstedt; Martin A Giedlin; Keith S Bahjat; Meredith L Leong; et al. (Profiled Author: Ajay Jain)
Immunology and Hematopoiesis Division, Department of Medical Oncology, Sidney Kimmel Cancer Center, Johns Hopkins Medical Institutions, 1650 Orleans Street, Baltimore, MD 21231, USA.
Cancer research 2006;66(2):1096-104.
Improved immunization and ex vivo T-cell culture strategies can generate larger numbers and more potent tumor-specific effector cells than previously possible. Nonetheless, the capacity of these cells to eliminate established tumors is limited by their ability to efficiently enter tumor-bearing organs and mediate their effector function. In the current study, we show that the administration of an engineered organ-homing microbe selectively targets tumor-specific immune responses to metastases within that organ. Specifically, an attenuated Listeria monocytogenes strain, which preferentially infects the liver following systemic administration, dramatically enhances the activity of a cancer vaccine against liver metastases but not metastases in the lung. This enhanced activity results from both local recruitment of innate immune effectors as well as concentration and increased activation of vaccine-induced antitumor T cells within the liver. These findings show a general approach to focus systemic cancer immunotherapies to specific organs bearing tumor metastases by taking advantage of differential tropisms and the proinflammatory nature of microbes.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Kiyoshi Yoshimura; Lindsay S Laird; Christina Y Chia; Kristen F Meckel; Jill E Slansky; John M Thompson; Ajay Jain; Drew M Pardoll; Richard D SchulickCancer research 2007;67(20):10058-66.
Tobias Hahn; Irene Alvarez; James J Kobie; Lalitha Ramanathapuram; Sharon Dial; Amy Fulton; David Besselsen; Edwin Walker; Emmanuel T AkporiayeInternational journal of cancer. Journal international du cancer 2006;118(9):2220-31.
Farhad Haghighi Rad; Hélène Le Buanec; Sébastien Paturance; Patrick Larcier; Philippe Genne; Bernhard Ryffel; Armand Bensussan; Bernard Bizzini; Robert C Gallo; Daniel Zagury; et al.Proceedings of the National Academy of Sciences of the United States of America 2007;104(8):2837-42.
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