The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
The potential role of mitochondria in pediatric traumatic brain injury.
Courtney L Robertson; Lucian Soane; Zachary T Siegel; Gary Fiskum (Profiled Author: Gary M Fiskum)
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA. firstname.lastname@example.org
Developmental neuroscience 2006;28(4-5):432-46.
Mitochondria play a central role in cerebral energy metabolism, intracellular calcium homeostasis and reactive oxygen species generation and detoxification. Following traumatic brain injury (TBI), the degree of mitochondrial injury or dysfunction can be an important determinant of cell survival or death. Literature would suggest that brain mitochondria from the developing brain are very different from those from mature animals. Therefore, aspects of developmental differences in the mitochondrial response to TBI can make the immature brain more vulnerable to traumatic injury. This review will focus on four main areas of secondary injury after pediatric TBI, including excitotoxicity, oxidative stress, alterations in energy metabolism and cell death pathways. Specifically, we will describe what is known about developmental differences in mitochondrial function in these areas, in both the normal, physiologic state and the pathologic state after pediatric TBI. The ability to identify and target aspects of mitochondrial dysfunction could lead to novel neuroprotective therapies for infants and children after severe TBI.
2 Originating Grant
MCKENNA, MARY C
1 May 1997 - 31 January 2014
EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH &HUMAN DEVELOPMENT
Zielke, H Ronald
1 May 1997 - 31 January 2009
NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Courtney L Robertson; Susanna Scafidi; Mary C McKenna; Gary FiskumExperimental neurology 2009;218(2):371-80.
G FiskumJournal of neurotrauma 2000;17(10):843-55.
Santina A Zanelli; Nina J Solenski; Robert E Rosenthal; Gary FiskumAnnals of the New York Academy of Sciences 2005;1053():153-61.
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