Peter Rock

Publication Detail

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Strain-related regional alterations of calcium-handling proteins in myocardial remodeling.

Ahmet Kilic; Tieluo Li; Timothy D C Nolan; Jennifer R Nash; Shuying Li; Deyanira J Prastein; Gary Schwartzbauer; Sina L Moainie; G Kwame Yankey; Christopher DeFilippi; et al. (Profiled Authors: Christopher Defilippi; Bartley P Griffith; Zhongjun Wu)

Division of Cardiac Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, Md 21201, USA.
The Journal of thoracic and cardiovascular surgery 2006;132(4):900-8.

BACKGROUND: Cardiac remodeling has been shown to have deleterious effects at both the global and local levels. The objective of this study is to investigate the role of strain in the initiation of structural and functional changes of myocardial tissue and its relation to alteration of calcium-handling proteins during cardiac remodeling after myocardial infarction. METHODS: Sixteen sonomicrometry transducers were placed in the left ventricular free wall of 9 sheep to measure the regional strain in the infarct, adjacent, and remote myocardial regions. Hemodynamic, echocardiographic, and sonomicrometry data were collected before myocardial infarction, after infarction, and 2, 6, and 8 weeks after infarction. Regional myocardial tissues were collected for calcium-handling proteins at the end study. RESULTS: At time of termination, end-systolic strains in 3 regionally distinct zones (remote, adjacent, and infarct) of myocardium were measured to be -14.65 +/- 1.13, -5.11 +/- 0.60 (P < or = .05), and 0.92 +/- 0.56 (P < or = .05), respectively. The regional end-systolic strain correlated strongly with the abundance of 2 major calcium-handling proteins: sarcoplasmic reticulum Ca2+ adenosine triphosphatase subtype 2a (r2 = 0.68, P < or = .05) and phospholamban (r2 = 0.50, P < or = .05). A lesser degree of correlation was observed between the systolic strain and the abundance of sodium/calcium exchanger type 1 protein (r2 = 0.17, P < or = .05). CONCLUSIONS: Regional strain differences can be defined in the different myocardial regions during postinfarction cardiac remodeling. These differences in regional strain drive regionally distinct alterations in calcium-handling protein expression.

3 Originating Grant

• 1.

  STANLEY, WILLIAM C

  Training Grant in Cardiac and Vascular Cell Biology

  1 April 2003 - 31 July 2014

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 2.

  Pallone, Thomas L

  Training Grant in Cardiac and Vascular Cell Biology

  1 April 2003 - 31 March 2008

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 3.

  Griffith, Bartley P

  BIOENGINEERING-BIOLOGIC STUDY OF NON-PULSATILE PERFUSION

  1 May 2000 - 30 April 2005

  NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

Scientific Context

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