Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.

M F Flajnik; C Canel; J Kramer; M Kasahara (Profiled Author: Martin F Flajnik)

Department of Microbiology and Immunology, University of Miami, FL 33101.
Proceedings of the National Academy of Sciences of the United States of America 1991;88(2):537-41.

Class I major histocompatibility complex (MHC) cDNA clones have been isolated from an expression library derived from mRNA of an MHC homozygous Xenopus laevis. The nucleotide and predicted amino acid sequences show definite similarity to MHC class I molecules of higher vertebrates. The immunoglobulin-like alpha-3 domain is more similar to the immunoglobulin-like domains of mammalian class II beta chains than to those of mammalian class I molecules, and a tree based on nucleotide sequences of representative MHC genes is presented.

2 Originating Grant

• 1.

  Flajnik, Martin F

  Ontogeny and Phylogeny of the MHC

  1 April 1989 - 30 April 2009

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 2.

  FLAJNIK, MARTIN F

  ONTOGENY AND PHYLOGENY OF THE MHC

  1 April 1989 - 31 March 1994

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Scientific Context

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