Marcela F Pasetti

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Cell-mediated immunity and the challenges for vaccine development.

Rosangela Salerno-Gonçalves; Marcelo B Sztein (Profiled Authors: Rosangela Noberga Mezghanni; Marcelo B Sztein)

Center for Vaccine Development, Department of Pediatrics, University of Maryland, 685 West Baltimore Street, HSF-1, Room 480, Baltimore, MD 21201, USA.
Trends in microbiology 2006;14(12):536-42.

One of the hallmarks of successful vaccination is the induction of strong and persistent memory T cell responses, a process that involves striking changes in the number and functional properties of T cells. Many questions pertaining to this complex, multifaceted process remain unanswered. Some of the key issues and challenges to optimize memory T cell responses and foster vaccine development include the optimization of effector T cell burst sizes, the use of adjuvants, cytokines and co-stimulatory molecules, epitope enhancement and the standardization of techniques to detect specific T cells. Age also has an impact on vaccine design because of the physiological changes in cell-mediated immunity that occur throughout life.

5 Originating Grant

• 1.

  Plowe, Christopher V

  Malaria Vaccine Trials in Mali

  1 September 2005 - 30 April 2010

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 2.

  PLOWE, CHRISTOPHER V.

  Genetic diversity and protective immunity to malaria infection and disease

  1 September 2005 - 30 June 2015

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 3.

  Sztein, Marcelo B

  Protective Immunity by Shigella vaccines in humans

  1 May 2004 - 30 April 2009

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 4.

  LEVINE, MYRON MAX

  Middle Atlantic Regional Center for Excellence for Biodefense and Emerging Infect

  4 September 2003 - 28 February 2014

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 5.

  SZTEIN, MARCELO B.

  Immune Mechanisms of Protection in S Typhi Vaccines

  1 September 1994 - 30 November 2011

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Scientific Context

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