Peter Rock

Publication Detail

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Relationship between vascular calcification and bone mineral density in the Old-order Amish.

H Shen; L F Bielak; E A Streeten; K A Ryan; J A Rumberger; P F Sheedy; A R Shuldiner; P A Peyser; B D Mitchell (Profiled Authors: Braxton D Mitchell Jr.; Alan R Shuldiner; Elizabeth Streeten)

Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, 660 W. Redwood Street, Room 492, Baltimore, MD 21201, USA.
Calcified tissue international 2007;80(4):244-50.

Vascular calcification and osteoporosis are common age-related processes that are influenced by both genetic and nongenetic factors. Whether common genes underlie these processes is not known. We measured coronary artery calcification (CAC), aortic calcification (AC), and bone mineral density (BMD) in 682 men and women from large Old-Order Amish families. We assessed the heritabilities of these traits and then evaluated, using variance decomposition procedures, whether variation in the traits was influenced by a common set of genes (i.e., pleiotropy). Significant heritabilities were detected for BMD of the femoral neck and spine (0.65, 0.63) and CAC and AC (0.43, 0.42). Mean BMD did not differ significantly across quartiles of either CAC or AC in either sex. In neither the total group nor any single subgroup (men, women, postmenopausal women) did any of the genetic or environmental correlations between BMD and vascular calcification achieve statistical significance. However, subjects with a history of cardiovascular disease (CVD) events had significantly lower BMD at the femoral neck compared to subjects who reported no prior history of CVD (age-, sex-, body mass index-, and family structure-adjusted P = 0.003). We detected no evidence for shared genes affecting the joint distribution of bone and vascular calcification. However, our results do reveal a lower BMD in subjects with a prior history of CVD in the Old-Order Amish.

4 Originating Grant

• 1.

  Shuldiner, Alan R

  Genome-wide Search for CVD Gene-Environment Interactions

  30 September 2002 - 31 May 2009

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 2.

  Reece, E Albert

  General Clinical Research Center

  1 March 2002 - 30 June 2010

  NATIONAL CENTER FOR RESEARCH RESOURCES

• 3.

  Mitchell, Braxton D

  Joint Determinants of Bone Density and CVD Calcification

  30 September 2001 - 31 July 2006

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 4.

  Shuldiner, Alan R

  GENETICS OF OSTEOPOROSIS IN THE AMISH

  1 September 2000 - 30 June 2007

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

Scientific Context

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