Alice S Ryan

Publication Detail

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Central activation, muscle performance, and physical function in men infected with human immunodeficiency virus.

Wayne B Scott; Krisann K Oursler; Leslie I Katzel; Alice S Ryan; David W Russ (Profiled Authors: Leslie I Katzel; Kris Ann K Kwiterovic Oursler; Alice S Ryan)

Department of Physical Therapy & Rehabilitation Science, School of Medicine, University of Maryland, 100 Penn Street, Baltimore, Maryland 21201-1082, USA.
Muscle & nerve 2007;36(3):374-83.

Loss of muscle mass and limitations in activity have been reported in persons infected with human immunodeficiency virus (HIV), even those who are otherwise asymptomatic. The extent to which factors other than muscle atrophy impair muscle performance has not been addressed in depth. The purpose of this study was to determine the extent of neuromuscular activation of the knee extensors and ankle dorsiflexors of 27 men infected with HIV receiving antiretroviral therapy and its relationship to muscle performance. The central activation ratio (CAR) was determined using superimposed electrical stimulation during maximum voluntary contractions. In addition to force and power measurements, muscle cross-sectional area and composition was evaluated using computed tomography. Aerobic capacity was determined from treadmill exercise testing. Eleven of the subjects had an impaired ability to activate the knee extensors (CAR = 0.72 +/- 0.12) that was associated with weakness and decreased specific force. The reduced central activation was not associated with muscle area, body composition, aerobic capacity, CD4 count, or medication regimen. Those individuals with low central activation had higher HIV-1 viral loads and were more likely to have a history of AIDS-defining illness. These results suggest the possibility of a different mechanism contributing to muscle impairment in the current treatment era that is associated with impairment of central motor function rather than atrophy. Further investigation is warranted in a larger, more diverse population before more definitive claims are made.

4 Originating Grant

• 1.

  Oursler, Krisann K

  Aging and Physical Functioning in HIV

  15 September 2009 - 31 August 2010

  NATIONAL INSTITUTE ON AGING

• 2.

  Reece, E Albert

  General Clinical Research Center

  1 March 2002 - 30 June 2010

  NATIONAL CENTER FOR RESEARCH RESOURCES

• 3.

  Ryan, Alice S

  Diet and Exercise: Race, Postmenopause and Metabolism

  30 September 2001 - 31 August 2007

  NATIONAL INSTITUTE ON AGING

• 4.

  Goldberg, Andrew P

  Claude D. Pepper Older Americans Independence Center (O*

  15 July 1994 - 31 August 2006

  NATIONAL INSTITUTE ON AGING

Scientific Context

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