Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis.

Kathy Lee; Gautam Adhikary; Sivaprakasam Balasubramanian; Ramamurthy Gopalakrishnan; Thomas McCormick; Goberdhan P Dimri; Richard L Eckert; Ellen A Rorke (Profiled Authors: Gautam Adhikary; Richard L Eckert; Sivaparkasam Balasubramanian)

Department of Physiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
The Journal of investigative dermatology 2008;128(1):9-17.

The polycomb group (PcG) genes are epigenetic suppressors of gene expression that play an important role in development. In this study, we examine the role of Bmi-1 (B-cell-specific Moloney murine leukemia virus integration site 1) as a regulator of human epidermal keratinocyte survival. We identify Bmi-1 mRNA and protein expression in epidermis and in cultured human keratinocytes. Bmi-1 is located in the nucleus in cultured keratinocytes, and in epidermis it is expressed in the basal and suprabasal layers. Adenovirus-delivered Bmi-1 promotes keratinocyte survival and protects keratinocytes from stress agent-mediated cell death. This is associated with increased levels of cyclin D1 and selected cyclin-dependent kinases, and reduced caspase activity and poly(ADP-ribose) polymerase (PARP) cleavage. Bmi-1 may be involved in the maintenance of disease state, as Bmi-1 levels are elevated in transformed keratinocytes, skin tumors, and psoriasis. The presence of Bmi-1 in suprabasal non-proliferative cells of the epidermis and within a high percentage of cells within skin tumors suggests a non-stem cell pro-survival role for Bmi-1 in this tissue. Based on the suprabasal distribution of Bmi-1 in epidermis, we propose that Bmi-1 may promote maintenance of suprabasal keratinocyte survival to prevent premature death during differentiation. Such a function would help assure proper formation of the stratified epidermis.

2 Originating Grant

• 1.

  ECKERT, RICHARD L

  Bmi-1 and Skin Cancer Prevention

  1 August 2008 - 31 May 2013

  NATIONAL CANCER INSTITUTE

• 2.

  ECKERT, RICHARD L

  Polycomb genes and keratinocyte function

  1 May 2008 - 28 February 2013

  NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES

Scientific Context

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