The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Sulfonylureas improve outcome in patients with type 2 diabetes and acute ischemic stroke.
Hagen Kunte; Sein Schmidt; Michael Eliasziw; Gregory J del Zoppo; J Marc Simard; Florian Masuhr; Markus Weih; Ulrich Dirnagl (Profiled Author: J Marc Simard)
Department of Neurology, Center for Stroke Research, Humboldt University, Berlin, Germany.
Stroke; a journal of cerebral circulation 2007;38(9):2526-30.
BACKGROUND AND PURPOSE: The sulfonylurea receptor 1-regulated NC(Ca-ATP) channel is upregulated in rodent models of stroke with block of the channel by the sulfonylurea, glibenclamide (glyburide), significantly reducing mortality, cerebral edema, and infarct volume. We hypothesized that patients with type 2 diabetes mellitus taking sulfonylurea agents both at the time of stroke and during hospitalization would have superior outcomes. METHODS: We reviewed medical records of patients with diabetes mellitus hospitalized within 24 hours of onset of acute ischemic stroke in the Neurology Clinic, Charité Hospital, Berlin, Germany, during 1994 to 2000. After exclusions, the cohort comprised 33 patients taking a sulfonylurea at admission through discharge (treatment group) and 28 patients not on a sulfonylurea (control group). The primary outcome was a decrease in National Institutes of Health Stroke Scale of 4 points or more from admission to discharge or a discharge National Institutes of Health Stroke Scale score of 0. The secondary outcome was a discharge modified Rankin Scale score < or =2. RESULTS: No significant differences, other than stroke subtype, were observed among baseline variables between control and treatment groups. The primary outcome was reached by 36.4% of patients in the treatment group and 7.1% in the control group (P=0.007). The secondary outcome was reached by 81.8% versus 57.1% (P=0.035). Subgroup analyses showed that improvements occurred only in patients with nonlacunar strokes and were independent of gender, previous transient ischemic attack, and blood glucose levels. CONCLUSIONS: Sulfonylureas may be beneficial for patients with diabetes mellitus with acute ischemic stroke. Further investigation of similar cohorts and a prospective randomized trial are recommended to confirm the present observations.
2 Originating Grant
SIMARD, J. MARC
19 January 2006 - 31 December 2015
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
15 September 2004 - 30 April 2008
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
J Marc Simard; Vladimir Yurovsky; Natalia Tsymbalyuk; Ludmila Melnichenko; Svetlana Ivanova; Volodymyr GerzanichStroke; a journal of cerebral circulation 2009;40(2):604-9.
J Marc Simard; S Kyoon Woo; Sergei Bhatta; Volodymyr GerzanichCurrent opinion in pharmacology 2008;8(1):42-9.
Mingkui Chen; Yafeng Dong; J Marc SimardThe Journal of neuroscience : the official journal of the Society for Neuroscience 2003;23(24):8568-77.
Appears in this Publication
Author of this Publication