The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
A secondary analysis of a duration response association between selective serotonin reuptake inhibitor use and the risk of acute myocardial infarction in the aging population.
Center for Pharmacoeconomic and Outcomes Research, Lovelace Respiratory Research Institute, Albuquerque, NM 87108, USA. cblanchette@Irri.org
Annals of epidemiology 2008;18(4):316-21.
PURPOSE: We assessed the risk of selective serotonin reuptake inhibitor (SSRI) use on the occurrence of acute myocardial infarction (AMI) based on duration of exposure. METHODS: A historical pooled cohort of all elderly, community-dwelling Medicare beneficiaries not enrolled in health maintenance organizations from the 1997 to 2001 Medicare Current Beneficiary Survey was constructed. SSRI users were compared with non-antidepressant users as well as other non-SSRI antidepressant users on their risk of AMI (ICD-9: 410 or 411). Descriptive statistics and binary logistic regression models were used to assess differences between groups. RESULTS: There were 1,052 SSRI users compared with 762 other antidepressant users and 10,856 nonantidepressant users. Logistic regression models revealed that SSRI users were found to have significantly greater odds of AMI compared with nonantidepressant users when controlling for age, gender, race, smoking history and current status, body mass index, depression, anxiety and diabetes (odds ratio 1.85; 95% confidence intervals 1.13-3.04). Stratification by prescription counts revealed those with more than three prescriptions had greater odds of AMI compared with nonusers (odds ratio 2.02, 95% confidence intervals 1.11-3.66). CONCLUSIONS: SSRI use leads to an increased risk of AMI in comparison with nonantidepressant use in an elderly population. The odds of AMI increased in those with more than three prescriptions in the preceding year, indicating a possible duration response relationship.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Christopher M Blanchette; Linda Simoni-Wastila; Fadia Shaya; Denise Orwig; Jason Noel; Bruce StuartAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 2009;66(4):366-72.
C Daniel Mullins; Fadia T Shaya; Fanlun Meng; Junling Wang; David HarrisonPharmacotherapy 2005;25(5):660-7.
E M Sullivan; R I Griffiths; R G Frank; M J Strauss; R J Herbert; J Clouse; H H GoldmanThe Journal of clinical psychiatry 2000;61(4):290-8.
Appears in this Publication
Author of this Publication