The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus.
David A Edwards; Longhua Zhang; Bradley E Alger (Profiled Author: Bradley E Alger)
Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(23):8142-7.
The modifiability of neuronal response plasticity is called "metaplasticity." In suppressing synaptic inhibition and facilitating induction of long-term excitatory synaptic plasticity, endocannabinoids (eCBs) act as agents of metaplasticity. We now report the discovery of a calcium-dependent mechanism that regulates eCB mobilization by metabotropic glutamate receptor (mGluR) activation. The switch-like mechanism primes cells to release eCBs and requires a transient rise in intracellular Ca2+ concentration ([Ca2+]i) but not concurrent activation of mGluRs. Conversely, short-term, [Ca2+]i-dependent eCB release can be persistently enhanced by mGluR activation. Hence, eCBs are also objects of metaplasticity, subject to higher levels of physiological control.
1 Originating Grant
Alger, Bradley E
30 September 1991 - 31 August 2006
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
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