Metaplastic control of the endocannabinoid system at inhibitory synapses in hippocampus.

Publication Detail

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David A Edwards; Longhua Zhang; Bradley E Alger (Profiled Author: Bradley E Alger)

Department of Physiology, Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Proceedings of the National Academy of Sciences of the United States of America 2008;105(23):8142-7.

PubMed

Abstract

The modifiability of neuronal response plasticity is called "metaplasticity." In suppressing synaptic inhibition and facilitating induction of long-term excitatory synaptic plasticity, endocannabinoids (eCBs) act as agents of metaplasticity. We now report the discovery of a calcium-dependent mechanism that regulates eCB mobilization by metabotropic glutamate receptor (mGluR) activation. The switch-like mechanism primes cells to release eCBs and requires a transient rise in intracellular Ca2+ concentration ([Ca2+]i) but not concurrent activation of mGluRs. Conversely, short-term, [Ca2+]i-dependent eCB release can be persistently enhanced by mGluR activation. Hence, eCBs are also objects of metaplasticity, subject to higher levels of physiological control.

1 Originating Grant

1.

Alger, Bradley E

Regulation of Inhibition in Hippocampus

30 September 1991 - 31 August 2006
NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

Scientific Context

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