The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction.
Monika K Duda; Karen M O'Shea; Anselm Tintinu; Wenhong Xu; Ramzi J Khairallah; Brian R Barrows; David J Chess; Agnes M Azimzadeh; William S Harris; Victor G Sharov; et al. (Profiled Authors: William C Stanley; Agnes Azimzadeh)
Division of Cardiology, Department of Medicine, University of Maryland-Baltimore, 20 Penn Street, HSF2, Room S022, Baltimore, MD 21201, USA.
Cardiovascular research 2009;81(2):319-27.
AIMS: Clinical studies suggest that intake of omega-3 polyunsaturated fatty acids (omega-3 PUFA) may lower the incidence of heart failure. Dietary supplementation with omega-3 PUFA exerts metabolic and anti-inflammatory effects that could prevent left ventricle (LV) pathology; however, it is unclear whether these effects occur at clinically relevant doses and whether there are differences between omega-3 PUFA from fish [eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] and vegetable sources [alpha-linolenic acid (ALA)]. METHODS AND RESULTS: We assessed the development of LV remodelling and pathology in rats subjected to aortic banding treated with omega-3 PUFA over a dose range that spanned the intake of humans taking omega-3 PUFA supplements. Rats were fed a standard food or diets supplemented with EPA+DHA or ALA at 0.7, 2.3, or 7% of energy intake. Without supplementation, aortic banding increased LV mass and end-systolic and -diastolic volumes. ALA supplementation had little effect on LV remodelling and dysfunction. In contrast, EPA+DHA dose-dependently increased EPA and DHA, decreased arachidonic acid in cardiac membrane phospholipids, and prevented the increase in LV end-diastolic and -systolic volumes. EPA+DHA resulted in a dose-dependent increase in the anti-inflammatory adipokine adiponectin, and there was a strong correlation between the prevention of LV chamber enlargement and plasma levels of adiponectin (r = -0.78). Supplementation with EPA+DHA had anti-aggregatory and anti-inflammatory effects as evidenced by decreases in urinary thromboxane B(2) and serum tumour necrosis factor-alpha. CONCLUSION: Dietary supplementation with omega-3 PUFA derived from fish, but not from vegetable sources, increased plasma adiponectin, suppressed inflammation, and prevented cardiac remodelling and dysfunction under pressure overload conditions.
2 Originating Grant
Stanley, William C
1 April 2008 - 31 March 2010
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
STANLEY, WILLIAM C
15 July 2003 - 31 July 2014
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Keyur B Shah; Monika K Duda; Karen M O'Shea; Genevieve C Sparagna; David J Chess; Ramzi J Khairallah; Isabelle Robillard-Frayne; Wenhong Xu; Robert C Murphy; Christine Des Rosiers; et al.Hypertension 2009;54(3):605-11.
Karen M O'Shea; Ramzi J Khairallah; Genevieve C Sparagna; Wenhong Xu; Peter A Hecker; Isabelle Robillard-Frayne; Christine Des Rosiers; Tibor Kristian; Robert C Murphy; Gary Fiskum; et al.Journal of molecular and cellular cardiology 2009;47(6):819-27.
Tatiana F Galvao; Ramzi J Khairallah; Erinne R Dabkowski; Bethany H Brown; Peter A Hecker; Kelly A O'Connell; Karen M O'Shea; Hani N Sabbah; Sharad Rastogi; Caroline Daneault; et al.American journal of physiology. Heart and circulatory physiology 2013;304(1):H12-21.
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