Peter Rock

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Bitter taste receptors influence glucose homeostasis.

Cedrick D Dotson; Lan Zhang; Hong Xu; Yu-Kyong Shin; Stephan Vigues; Sandra H Ott; Amanda E T Elson; Hyun Jin Choi; Hillary Shaw; Josephine M Egan; et al. (Profiled Authors: Braxton D Mitchell Jr.; Nanette I Steinle; Stephan Vigues; Steven D Munger)

Department of Anatomy & Neurobiology, University of Maryland School of Medicine, Baltimore, MD, USA.
PloS one 2008;3(12):e3974.

TAS1R- and TAS2R-type taste receptors are expressed in the gustatory system, where they detect sweet- and bitter-tasting stimuli, respectively. These receptors are also expressed in subsets of cells within the mammalian gastrointestinal tract, where they mediate nutrient assimilation and endocrine responses. For example, sweeteners stimulate taste receptors on the surface of gut enteroendocrine L cells to elicit an increase in intracellular Ca(2+) and secretion of the incretin hormone glucagon-like peptide-1 (GLP-1), an important modulator of insulin biosynthesis and secretion. Because of the importance of taste receptors in the regulation of food intake and the alimentary responses to chemostimuli, we hypothesized that differences in taste receptor efficacy may impact glucose homeostasis. To address this issue, we initiated a candidate gene study within the Amish Family Diabetes Study and assessed the association of taste receptor variants with indicators of glucose dysregulation, including a diagnosis of type 2 diabetes mellitus and high levels of blood glucose and insulin during an oral glucose tolerance test. We report that a TAS2R haplotype is associated with altered glucose and insulin homeostasis. We also found that one SNP within this haplotype disrupts normal responses of a single receptor, TAS2R9, to its cognate ligands ofloxacin, procainamide and pirenzapine. Together, these findings suggest that a functionally compromised TAS2R receptor negatively impacts glucose homeostasis, providing an important link between alimentary chemosensation and metabolic disease.

4 Originating Grant

• 1.

  Vigues, Stephan

  The structural basis of L-amino acid taste

  15 June 2006 - 31 May 2009

  NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

• 2.

  SHULDINER, ALAN R.

  Mid-Atlantic Nutrition Obesity Research Center

  15 September 2005 - 31 August 2015

  NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

• 3.

  Steinle, Nanette Irene

  Cloning a Blood Pressure Gene on Human Chromosome 2q32.3

  1 July 2005 - 30 June 2009

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 4.

  Munger, Steven D

  Chemosensory receptors and the basis of specificity

  20 September 2002 - 31 August 2009

  NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS

Scientific Context

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