The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Vaccination in the elderly: an immunological perspective.
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA. firstname.lastname@example.org
Trends in immunology 2009;30(7):351-9.
Successful vaccination of the elderly against important infectious pathogens that cause high morbidity and mortality represents a growing public health priority. Building on the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly compared with that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines.
2 Originating Grant
Shuldiner, Alan R
23 September 2005 - 31 July 2010
NATIONAL CENTER FOR RESEARCH RESOURCES
SZTEIN, MARCELO B.
1 September 1994 - 30 November 2011
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
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