Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Vaccination in the elderly: an immunological perspective.

Wilbur H Chen; Bernard F Kozlovsky; Rita B Effros; Beatrix Grubeck-Loebenstein; Robert Edelman; Marcelo B Sztein (Profiled Authors: Marcelo B Sztein; Wilbur H Chen)

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA. wchen@medicine.umaryland.edu
Trends in immunology 2009;30(7):351-9.

Successful vaccination of the elderly against important infectious pathogens that cause high morbidity and mortality represents a growing public health priority. Building on the theme of aging and immunosenescence, we review mechanisms of human immunosenescence and the immune response to currently licensed vaccines. We discuss the difficulties in identifying the risk factors that, in addition to aging, cause immunosenescence and address the relative paucity of vaccine studies in the elderly. We conclude that vaccine responses are blunted in the elderly compared with that of healthy young adults. However, it is also clear that our understanding of the mechanisms underlying immunosenescence is limited and much remains to be learned to improve the effectiveness of next generation vaccines.

2 Originating Grant

• 1.

  Shuldiner, Alan R

  Clinical Research Career Development (RMI)

  23 September 2005 - 31 July 2010

  NATIONAL CENTER FOR RESEARCH RESOURCES

• 2.

  SZTEIN, MARCELO B.

  Immune Mechanisms of Protection in S Typhi Vaccines

  1 September 1994 - 30 November 2011

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Scientific Context

This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.