The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Aspirin Resistance in healthy drug-naive men versus women (from the Heredity and Phenotype Intervention Heart Study).
Haiqing Shen; William Herzog; MaryAnn Drolet; Ruth Pakyz; Sylvia Newcomer; Paul Sack; Heidi Karon; Kathleen A Ryan; Yiju Zhao; Xiaolian Shi; et al. (Profiled Authors: Braxton D Mitchell Jr.; Alan R Shuldiner)
Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA.
The American journal of cardiology 2009;104(4):606-12.
This study was designed to determine the factors that contribute to interindividual variation in the antiplatelet effects of aspirin. We measured platelet response to aspirin in 745 (400 men and 345 women) drug-naive asymptomatic subjects of the Heredity and Phenotype Intervention (HAPI) Heart Study. Whole blood platelet aggregometry was performed to assess response to arachidonic acid, adenosine diphosphate, and collagen at baseline and after 14 days of aspirin 81 mg/day. There was wide interindividual variation in platelet aggregation in response to aspirin, with no clear biological threshold to define aspirin resistance. Variation in platelet function before and after aspirin was heritable. Women exhibited greater platelet aggregability in response to adenosine diphosphate and collagen at baseline and after aspirin administration. The degree to which aspirin inhibited collagen-induced platelet aggregation was also significantly less in women compared with men (mean +/- SD percent inhibition of collagen-induced [1 microg/ml] platelet aggregation 49.9 +/- 30.9 vs 57.5 +/- 42.5 in women and men, respectively, p = 0.005). Using a cutoff <70% inhibition of collagen-induced platelet aggregation, 21% of the total population demonstrated aspirin resistance, which occurred in 30% of women and 16% of men (p = 0.0002). Aspirin-resistant subjects were older, had significantly higher total cholesterol and low-density lipoprotein cholesterol levels, lower hematocrit, and higher platelet count compared with aspirin-sensitive subjects. In conclusion, in this study group, platelet function is heritable. There is wide interindividual variation in platelet response to aspirin as defined by whole blood platelet aggregometry, with women having lower mean percent inhibition of platelet aggregation and greater prevalence of aspirin resistance than men.
4 Originating Grant
Shuldiner, Alan R
23 September 2005 - 31 August 2010
NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
SHULDINER, ALAN R.
15 September 2005 - 31 August 2015
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
Shuldiner, Alan R
30 September 2002 - 31 May 2009
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
Reece, E Albert
1 March 2002 - 30 June 2010
NATIONAL CENTER FOR RESEARCH RESOURCES
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Braxton D Mitchell; Patrick F McArdle; Haiqing Shen; Evadnie Rampersaud; Toni I Pollin; Lawrence F Bielak; Cashell Jaquish; Julie A Douglas; Marie-Hélène Roy-Gagnon; Paul Sack; et al.American heart journal 2008;155(5):823-8.
Maribeth Friend; Ivana Vucenik; Michael MillerBMJ (Clinical research ed.) 2003;326(7380):82-3.
Katrin Sangkuhl; Alan R Shuldiner; Teri E Klein; Russ B AltmanPharmacogenetics and genomics 2011;21(8):516-21.
Appears in this Publication
Author of this Publication