The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Prevalence of antimicrobial-resistant bacteria isolated from older versus younger hospitalized adults: results of a two-centre study.
Stephen G Weber; Ram R Miller; Eli N Perencevich; Jocelyn Tolentino; David Meltzer; David Pitrak; Jessina C McGregor; Greg A Sachs; Anthony D Harris; Jon P Furuno (Profiled Authors: Anthony D Harris; Ram R Miller)
Section of Infectious Diseases, University of Chicago, Chicago, IL, USA. firstname.lastname@example.org
The Journal of antimicrobial chemotherapy 2009;64(6):1291-8.
OBJECTIVES: To compare the proportion of antimicrobial-resistant strains among bacterial isolates from younger and older hospital patients and to quantify changes in the proportion of antimicrobial-resistant strains in both groups over time. PATIENTS AND METHODS: A retrospective analysis of microbiology data from two centres in Maryland and Chicago was performed. Adult hospital inpatients with positive clinical cultures for specific antimicrobial-resistant bacterial pathogens between 1999 and 2005 (55 427 isolates) were included. The proportions of isolates not susceptible to specific antimicrobial agents were compared between patients > or =65 and <65 years. Additional analyses examined temporal trends in the frequency of resistance and the frequency of resistance among the oldest patients (> or =80 years), in bacteria isolated from blood cultures and in bacteria obtained from intensive care unit patients. RESULTS: Heterogeneity was observed in the frequency of resistance among different bacteria between older and younger patients, between the two centres and over the study period. Staphylococcus aureus isolates were more likely to be resistant to methicillin when obtained from older patients at Chicago (50.9% versus 40.9%; P < 0.001). In contrast, younger patients yielded a greater proportion of enterococci resistant to vancomycin at Maryland (19.4% versus 16.5%; P = 0.009). Results were variable when resistance to fluoroquinolones, cephalosporins and imipenem were compared for Pseudomonas aeruginosa, Escherichia coli and Klebsiella spp. CONCLUSIONS: Overall, advanced patient age was not uniformly associated with a greater likelihood of antimicrobial resistance among all bacterial pathogens. Moreover, the frequency of resistance in older and younger patients varied considerably at the two sites over the study period. Variability in the frequency of resistance precludes simplistic conclusions regarding the relationship between age and resistance.
3 Originating Grant
HARRIS, ANTHONY D
30 September 2006 - 29 September 2010
NATIONAL CENTER FOR INFECTIOUS DISEASES (NCID)
Shuldiner, Alan R
23 September 2005 - 31 July 2010
NATIONAL CENTER FOR RESEARCH RESOURCES
Goldberg, Andrew P
15 July 1994 - 31 August 2006
NATIONAL INSTITUTE ON AGING
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Graham M Snyder; Kerri A Thom; Jon P Furuno; Eli N Perencevich; Mary-Claire Roghmann; Sandra M Strauss; Giora Netzer; Anthony D HarrisInfection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2008;29(7):583-9.
Stephen G Weber; Susan S Huang; Shannon Oriola; W Charles Huskins; Gary A Noskin; Kathleen Harriman; Russell N Olmsted; Marc Bonten; Tammy Lundstrom; Michael W Climo; et al.
Legislative mandates for use of active surveillance cultures to screen for methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci: Position statement from the Joint SHEA and APIC Task Force.American journal of infection control 2007;35(2):73-85.
Jon P Furuno; Jessina C McGregor; Anthony D Harris; Judith A Johnson; Jennifer K Johnson; Patricia Langenberg; Richard A Venezia; Joseph Finkelstein; David L Smith; Sandra M Strauss; et al.Archives of internal medicine 2006;166(5):580-5.
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