The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
New and candidate vaccines for gastrointestinal infections.
Jakub Simon; Karen Kotloff (Profiled Author: Karen L Kotloff)
Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Current opinion in gastroenterology 2010;26(1):12-6.
PURPOSE OF REVIEW: To summarize recent advances that contribute to the development of new vaccines against gastrointestinal infections. RECENT FINDINGS: The main themes of this review include epidemiology assessing disease burden of enteric pathogens, increasing antibiotic resistance, positive effect of existing enteric vaccines in developed and developing countries, and recommendations of advisory bodies; antigen discovery and preclinical testing, including live vector systems expressing heterologous antigens, conjugation of antigen to carrier proteins, and plant-based expression systems; as well as clinical studies highlighting recently published enteric vaccine candidates, studies assessing immune correlates of protection, as well as a trend for technology transfer to developing countries where enteric vaccines can be produced less expensively. SUMMARY: It is an exciting time for the development of novel vaccines against gastrointestinal infections. Better understanding of disease burden, interest from funding sources, identification of novel antigens, better understanding of protective immune responses, and steady progress in the conduct of clinical trials make the development of new enteric vaccines a goal that is attainable in the near future.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Mara Dinits-Pensy; Graeme N Forrest; Alan S Cross; Michael K HiseAmerican journal of kidney diseases : the official journal of the National Kidney Foundation 2005;46(6):997-1011.
Wilbur H Chen; Bernard F Kozlovsky; Rita B Effros; Beatrix Grubeck-Loebenstein; Robert Edelman; Marcelo B SzteinTrends in immunology 2009;30(7):351-9.
M M LevineLancet 1974;2(7871):34-8.
Appears in this Publication
Author of this Publication