Peter Rock

Publication Detail

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Resistance to the antilipolytic effect of insulin in adipocytes of African-American compared to Caucasian postmenopausal women.

Susan K Fried; Thomas Tittelbach; Jacob Blumenthal; Urmila Sreenivasan; Linda Robey; Jamie Yi; Sumbul Khan; Courtney Hollender; Alice S Ryan; Andrew P Goldberg (Profiled Authors: Andrew P Goldberg; Alice S Ryan; Jacob B Blumenthal)

Geriatric Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA. skfried@bu.edu
Journal of lipid research 2010;51(5):1193-200.

High fatty acid (FA) flux is associated with systemic insulin resistance, and African-American (AA) women tend to be more insulin resistant. We assessed possible depot and race difference in the antilipolytic effect of insulin in adipocytes isolated from abdominal (Abd) and gluteal (Glt) subcutaneous (sc) adipose tissue of overweight, postmenopausal AA and Caucasian (C) women. Percent body fat, fasting insulin, visceral adiposity, and adipocyte size was higher in AA women. Disinhibited lipolysis (presence of adenosine deaminase) per unit adipocyte surface area was similar in Abd and Glt and in AA and C. However, rates of 'basal' [submaximal phenylisopropyl adenosine (PIA)-suppressed] and insulin-suppressed lipolysis were higher in Abd of AA compared with C women even after adjustment for percent fat and visceral fat area. The race difference in rates of PIA- and insulin-suppressed lipolysis in AA were correlated with their hyperinsulinemia, but AA race, independent of fasting insulin, was associated with lower responsiveness (percent suppression) to submaximal insulin concentrations, although sensitivity (ED50) was not affected. Overall, these data are consistent with the hypothesis that decreased responsiveness of Abd adipocytes to antilipolytic effectors may contribute to higher FA availability and thereby to racial differences in insulin resistance.

4 Originating Grant

• 1.

  SHULDINER, ALAN R.

  Mid-Atlantic Nutrition Obesity Research Center

  15 September 2005 - 31 August 2015

  NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

• 2.

  Goldberg, Andrew P

  Race, Lipoprotein Lipase and Obesity after Menopause

  1 April 2003 - 31 March 2009

  NATIONAL INSTITUTE ON AGING

• 3.

  Ryan, Alice S

  Diet and Exercise: Race, Postmenopause and Metabolism

  30 September 2001 - 31 August 2007

  NATIONAL INSTITUTE ON AGING

• 4.

  GOLDBERG, ANDREW P

  The Biology of Exercise, Metabolism and Aging

  30 September 1992 - 30 April 2014

  NATIONAL INSTITUTE ON AGING

Scientific Context

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