Peter Rock

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

New loci associated with kidney function and chronic kidney disease.

Anna Köttgen; Cristian Pattaro; Carsten A Böger; Christian Fuchsberger; Matthias Olden; Nicole L Glazer; Afshin Parsa; Xiaoyi Gao; Qiong Yang; Albert V Smith; et al. (Profiled Authors: Braxton D Mitchell Jr.; Jeffrey R O'Connell; Afshin Parsa; Alan R Shuldiner)

Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Nature genetics 2010;42(5):376-84.

Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.

15 Originating Grant

• 1.

  Mitchell, Braxton D

  Genetic Risk to Stroke in Smokers and Nonsmokers in Two Ethnic Groups

  20 September 2008 - 30 June 2010

  NATIONAL HUMAN GENOME RESEARCH INSTITUTE

• 2.

  MITCHELL, BRAXTON D

  Genetic Influences on Coronary Artery Calcification

  1 September 2007 - 30 June 2011

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 3.

  Shuldiner, Alan R

  Pharmacogenomics of CVD risk Reduction

  23 September 2005 - 31 August 2010

  NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

• 4.

  Shuldiner, Alan R

  Clinical Research Career Development (RMI)

  23 September 2005 - 31 July 2010

  NATIONAL CENTER FOR RESEARCH RESOURCES

• 5.

  SHULDINER, ALAN R.

  Mid-Atlantic Nutrition Obesity Research Center

  15 September 2005 - 31 August 2015

  NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES

• 6.

  Shuldiner, Alan R

  Genome-wide Search for CVD Gene-Environment Interactions

  30 September 2002 - 31 May 2009

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 7.

  Shuldiner, Alan R

  Longevity Genes in Founder Populations

  15 July 2001 - 30 June 2006

  NATIONAL INSTITUTE ON AGING

• 8.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY

• 9.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY-ECHOCARDIOGRAPHY READING CTR

• 10.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY READING CENTER

• 11.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY

• 12.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY

• 13.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY

• 14.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY

• 15.

  GOTTDIENER, JOHN S

  CARDIOVASCULAR HEALTH STUDY--ECHOCARDIOGRAPHY

Scientific Context

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