The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Critical role of IL-25 in nematode infection-induced alterations in intestinal function.
Aiping Zhao; Joseph F Urban; Rex Sun; Jennifer Stiltz; Motoko Morimoto; Luigi Notari; Kathleen B Madden; Zhonghan Yang; Viktoriya Grinchuk; Thirumalai R Ramalingam; et al. (Profiled Authors: Terez Shea-Donohue; Aiping M Zhao; Luigi Notari)
Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA. email@example.com
Journal of immunology (Baltimore, Md. : 1950) 2010;185(11):6921-9.
IL-25 (IL-17E) is a member of the IL-17 cytokine family. IL-25-deficient mice exhibit impaired Th2 immunity against nematode infection, implicating IL-25 as a key component in mucosal immunity. The sources of IL-25 and mechanisms responsible for the induction of Th2 immunity by IL-25 in the gastrointestinal tract remain poorly understood. There is also little information on the regulation of IL-25 during inflammation or its role in gut function. In the current study, we investigated the regulation of IL-25 during Nippostrongylus brasiliensis infection and the contribution of IL-25 to the infection-induced alterations in intestinal function. We found that epithelial cells, but not immune cells, are the major source of IL-25 in the small intestine. N. brasiliensis infection-induced upregulation of IL-25 depends upon IL-13 activation of STAT6. IL-25(-/-) mice had diminished intestinal smooth muscle and epithelial responses to N. brasiliensis infection that were associated with an impaired Th2 protective immunity. Exogenous IL-25 induced characteristic changes similar to those after nematode infection but was unable to restore the impaired host immunity against N. brasiliensis infection in IL-13(-/-) mice. These data show that IL-25 plays a critical role in nematode infection-induced alterations in intestinal function that are important for host protective immunity, and IL-13 is the major downstream Th2 cytokine responsible for the IL-25 effects.
1 Originating Grant
1 June 2009 - 31 March 2014
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
Aiping Zhao; Joseph F Urban; Robert M Anthony; Rex Sun; Jennifer Stiltz; Nico van Rooijen; Thomas A Wynn; William C Gause; Terez Shea-DonohueGastroenterology 2008;135(1):217-225.e1.
Motoko Morimoto; Aiping Zhao; Rex Sun; Jennifer Stiltz; Kathleen B Madden; Margaret Mentink-Kane; Thirumalai Ramalingam; Thomas A Wynn; Joseph F Urban; Terez Shea-DonohueJournal of immunology (Baltimore, Md. : 1950) 2009;183(3):1934-9.
Aiping Zhao; Motoko Morimoto; Harry Dawson; Justin E Elfrey; Kathleen B Madden; William C Gause; Booki Min; Fred D Finkelman; Joseph F Urban; Terez Shea-DonohueJournal of immunology (Baltimore, Md. : 1950) 2005;175(4):2563-9.
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