The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Mucosal IgA responses in healthy adult volunteers following intranasal spray delivery of a live attenuated measles vaccine.
Jakub K Simon; Karina Ramirez; Lilian Cuberos; James D Campbell; Jean F Viret; Alma Muñoz; Rosanna Lagos; Myron M Levine; Marcela F Pasetti (Profiled Authors: Myron M Levine; Marcela F Pasetti; James D Campbell)
Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Room 480, Baltimore, MD 21201, USA. email@example.com
Clinical and vaccine immunology : CVI 2011;18(3):355-61.
Measles remains an important cause of morbidity and mortality among children in the developing world. The goal of this study was to examine measles virus-specific mucosal immune responses in healthy immune (n = 24; plaque reduction neutralization [PRN] titers of ≥200 mIU/ml) and nonimmune (n = 24) young adult volunteers who received the monovalent Moraten measles vaccine via intranasal (spray delivery) or subcutaneous immunization. Serum, oral fluid, and nasal wash samples were examined for measles virus-specific and total IgG and IgA on day 0 (prior to vaccination) and on days 14, 28, and 90 after vaccination. Nonimmune subjects vaccinated subcutaneously developed high levels of measles virus PRN, IgG, and IgA antibodies in serum, oral fluid, and nasal washes. Total IgG and secretory IgA (sIgA) titers were increased in nasal washes, and total IgG was increased in oral fluid specimens. There was a strong correlation between PRN and measles virus-specific IgG titers measured in serum, oral fluid, and nasal washes, whereas a weak correlation was found between PRN and measles virus-specific IgA titers. Notably, intranasal measles vaccination resulted in increased production of measles virus-specific sIgA in oral fluid and nasal washes in nonimmune individuals, without evidence of a systemic immune response. In contrast, no significant vaccine-induced responses were observed in immune subjects, regardless of the route of immunization. These results demonstrate that (i) intranasal measles immunization can elicit a mucosal response independent of the induction of serum antibodies and (ii) both mucosal and systemic antibody responses following nasal or subcutaneous immunization are blunted by preexisting measles immunity.
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Jakub K Simon; Marcela F Pasetti; Jean-François Viret; Robert Mischler; Alma Muñoz; Rosanna Lagos; Myron M Levine; James D CampbellHuman vaccines 2007;3(2):54-8.
Marcela F Pasetti; Eileen M Barry; Genevieve Losonsky; Mahender Singh; Sandra M Medina-Moreno; John M Polo; Jeffrey Ulmer; Harriet Robinson; Marcelo B Sztein; Myron M Levine
Attenuated Salmonella enterica serovar Typhi and Shigella flexneri 2a strains mucosally deliver DNA vaccines encoding measles virus hemagglutinin, inducing specific immune responses and protection in cotton rats.Journal of virology 2003;77(9):5209-17.
M F Pasetti; A Resendiz-Albor; K Ramirez; R Stout; M Papania; R J Adams; F P Polack; B J Ward; D Burt; S Chabot; et al.Clinical pharmacology and therapeutics 2007;82(6):672-85.
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