Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Nanoparticle-functionalized porous polymer monolith detection elements for surface-enhanced Raman scattering.

Jikun Liu; Ian White; Don L DeVoe (Profiled Author: DonL DeVoe)

Department of Mechanical Engineering, University of Maryland, College Park, Maryland 20742, United States.
Analytical chemistry 2011;83(6):2119-24.

The use of porous polymer monoliths functionalized with silver nanoparticles is introduced in this work for high-sensitivity surface-enhanced Raman scattering (SERS) detection. Preparation of the SERS detection elements is a simple process comprising the synthesis of a discrete polymer monolith section within a silica capillary, followed by physically trapping silver nanoparticle aggregates within the monolith matrix. A SERS detection limit of 220 fmol for Rhodamine 6G is demonstrated, with excellent signal stability over a 24 h period. The capability of the SERS-active monolith for label-free detection of biomolecules was demonstrated by measurements of bradykinin and cytochrome c. The SERS-active monoliths can be readily integrated into miniaturized micrototal-analysis systems for online and label-free detection for a variety of biosensing, bioanalytical, and biomedical applications.

4 Originating Grant

• 1.

  DEVOE, DON L

  Single Molecule Mass Spectrometry in a Microfluidic Nanopore Chip

  1 September 2010 - 31 August 2011

  NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

• 2.

  DEVOE, DON L

  Microfluidic Platform for Probing Ceramide Channels

  1 April 2009 - 31 March 2011

  NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

• 3.

  WHITE, IAN M

  Highly Sensitive Biosensor Platform Using Optical Microring Resonators

  18 September 2006 - 31 August 2011

  NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING

• 4.

  Devoe, Don L

  Proteomics of Cell Death via 2-D Micorfluidic Profiling

  15 September 2005 - 31 August 2009

  NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES

Scientific Context

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