Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Mouse models to assess the efficacy of non-typhoidal Salmonella vaccines: revisiting the role of host innate susceptibility and routes of challenge.

Raphael Simon; Sharon M Tennant; James E Galen; Myron M Levine (Profiled Authors: James E Galen; Myron M Levine; Sharon Tennant; Raphael Simon)

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD, 21201, USA. rsimon@medicine.umaryland.edu
Vaccine 2011;29(32):5094-106.

Non-typhoidal Salmonella enterica (NTS) serovars Typhimurium and Enteritidis are important causes of bacterial gastroenteritis in the USA and worldwide. In sub-Saharan Africa these two serovars are emerging as agents associated with lethal invasive disease (e.g., bacteremia, meningitis). The development of NTS vaccines, based on mucosally administered live attenuated strains and parenteral non-living antigens, could diminish the NTS disease burden globally. Mouse models of S. Typhimurium and S. Enteritidis invasive disease can accelerate the development of NTS vaccines. Live attenuated NTS vaccines elicit both cellular and humoral immunity in mice and their efficacy is well established. In contrast, non-living vaccines that primarily elicit humoral immunity have demonstrated variable efficacy. An analysis of the reported studies with non-living vaccines against S. Typhimurium and S. Enteritidis reveals that efficacy is influenced by two important independent variables: (1) the innate susceptibility to NTS infection that differs dramatically between commonly used mouse strains and (2) the virulence of the NTS strain used for challenge. Protection by non-living vaccines has generally been seen only in host-pathogen interactions where a sub-lethal infection results, such as challenging resistant mice with either highly virulent or weakly virulent strains or susceptible mice with weakly virulent strains. The immunologic basis of this discrepancy and the implications for human NTS vaccine development are reviewed herein.

2 Originating Grant

• 1.

  LEVINE, MYRON MAX

  Middle Atlantic Regional Center for Excellence for Biodefense and Emerging Infect

  4 September 2003 - 28 February 2014

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

• 2.

  LEVINE, MYRON MAX

  Fellowship Training Program in Vaccinology

  1 July 1997 - 30 June 2012

  NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES

Scientific Context

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