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Kevin J Cullen

Kevin J Cullen

School of Medicine

Medicine

School of Medicine

Program in Oncology

School of Medicine

Pharmacology and Experimental Therapeutics

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Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.



GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response.

Baishen Chen; Xi Rao; Michael G House; Kenneth P Nephew; Kevin J Cullen; Zhongmin Guo (Profiled Author: Kevin J Cullen)

Medical Sciences Program, Indiana University School of Medicine, 1001 E. Third St., Bloomington, IN, USA.
Cancer letters 2011;309(1):37-45.

Abstract

Glutathione peroxidase 3 (GPx3), a plasma antioxidant enzyme, maintains genomic integrity by inactivating reactive oxygen species (ROS), known DNA-damaging agents and mediators of cancer chemotherapy response. In this study, we demonstrate that loss of GPx3 expression by promoter hypermethylation is frequently observed in a wide spectrum of human malignancies. Furthermore, GPx3 methylation correlates with head and neck cancer (HNC) chemoresistance and may serve as a potential prognostic indicator for HNC patients treated with cisplatin-based chemotherapy. Our findings support the hypothesis that defects in the antioxidant system may contribute to tumorigenesis of a wide spectrum of human malignancies. GPx3 methylation may have implications in chemotherapy response and clinical outcome of HNC patients.

Scientific Context

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