J Marc Simard

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When replication teaches more than the original experiment--the saga of the unknown unknown.

J Marc Simard; Volodymyr Gerzanich (Profiled Authors: Vladimir V Gerzanich; J Marc Simard)

Department of Neurosurgery, University of Maryland School of Medicine, Baltimore, MD 21201, USA. msimard@smail.umaryland.edu
Experimental neurology 2012;233(2):623-4.

We recently published a description of the molecular mechanism involved in "progressive hemorrhagic necrosis", a pathological process that evolves during several hours after spinal cord injury, that is attributable to progressive capillary fragmentation, and that is due to upregulation and activation of SUR1-regulated channels in microvascular endothelium. In this commentary, we reflect on the independent replication of our original experiment by Dr. Phillip Popovich and colleagues, and how their initial attempt at replication led to the unexpected finding that anisotropy of spinal cord tissues strongly influences the patterns of both primary and secondary hemorrhage that are observed after impact injury to the spinal cord.

2 Originating Grant

• 1.

  SIMARD, J. MARC

  Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel

  15 February 2009 - 31 January 2014

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

• 2.

  GERZANICH, VLADIMIR

  TRPM4 channel in spinal cord injury

  1 August 2008 - 31 May 2013

  NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE

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