Peter Rock

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.

Update on lipids and mitochondrial function: impact of dietary n-3 polyunsaturated fatty acids.

William C Stanley; Ramzi J Khairallah; Erinne R Dabkowski (Profiled Author: William C Stanley)

Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA. wstanley@medicine.umaryland.edu
Current opinion in clinical nutrition and metabolic care 2012;15(2):122-6.

PURPOSE OF REVIEW: Recent evidence has linked n-3 polyunsaturated fatty acid (PUFA) supplementation with dramatic alterations of mitochondrial phospholipid membranes and favorable changes in mitochondrial function. In the present review, we examine the novel effects of n-3 PUFA on mitochondria, with an emphasis on cardiac mitochondrial phospholipids. RECENT FINDINGS: There is growing evidence that dietary n-3 PUFA, particularly docosahexaenoic acid (DHA), has profound effects on mitochondrial membrane phospholipid composition and mitochondrial function. Supplementation with n-3 PUFA increases membrane phospholipid DHA and depletes arachidonic acid, and can increase cardiolipin, a tetra-acyl phospholipid that is unique to mitochondrial and essential for optimal mitochondrial function. Recent studies show that supplementation with DHA decreases propensity for cardiac mitochondria to undergo permeability transition, a catastrophic event often leading to cell death. This finding provides a potential mechanism for the cardioprotective effect of DHA. Interestingly, other n-3 PUFAs that modify membrane composition to a lesser extent have substantially less of an effect on mitochondria and do not appear to directly protect the heart. SUMMARY: Current data support a role for n-3 PUFA supplementation, particularly DHA, on mitochondria that are strongly associated with changes in mitochondrial phospholipid composition.

4 Originating Grant

• 1.

  STANLEY, WILLIAM C

  Docosahexaenoic Acid for Treatment of Heart Failure

  1 April 2010 - 31 March 2012

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 2.

  STANLEY, WILLIAM C

  Cardiac Energy Metabolism in Heart Failure

  15 July 2003 - 31 July 2014

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 3.

  STANLEY, WILLIAM C

  Training Grant in Cardiac and Vascular Cell Biology

  1 April 2003 - 31 July 2014

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

• 4.

  Pallone, Thomas L

  Training Grant in Cardiac and Vascular Cell Biology

  1 April 2003 - 31 March 2008

  NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

Scientific Context

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