The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
A correlation of bombesin-responsiveness with myc-family gene expression in small cell lung carcinoma cell lines.
E A Sausville; J D Moyer; R Heikkila; L M Neckers; J B Trepel (Profiled Author: Edward A Sausville)
National Cancer Institute-Navy Medical Oncology Branch, Bethesda, Maryland 20814.
Annals of the New York Academy of Sciences 1988;547():310-21.
Bombesin is a 14 amino acid peptide originally isolated from amphibian skin; its mammalian homolog is gastrin-releasing peptide (GRP). GRP is found in a high proportion of human small cell lung cancer (SCLC) cell lines. [Tyr4]bombesin caused an increase in intracellular Ca2+ ([Ca2+]i) in 5/11 SCLC cell lines tested. Bombesin action was not inhibited by agents known to alter the plasma membrane potential, nor did replacement of external Na+ with choline affect the bombesin-induced signal. [Tyr4]bombesin did not itself affect the membrane potential. Chelation of external Ca2+ reduced but did not prevent the bombesin-evoked increase in [Ca2+]i. This suggested that in SCLC, bombesin congeners not only promote an influx of extracellular Ca2+ but also release Ca2+ from intracellular stores. [Tyr4]bombesin increased levels of inositol 1,4,5-trisphosphate within seconds of addition to SCLC cell cultures and enhanced the accumulation of inositol 1-phosphate and inositol 4-phosphate in the presence of Li+. The SCLC cell lines responsive to bombesin constitutively expressed L-myc and did not express c-myc or N-myc. In contrast, SCLC cells non-responsive to bombesin had prominent constitutive expression of c-myc or N-myc with or without L-myc expression. Responding cell lines also had constitutive expression of the preproGRP gene, while non-responding cell lines showed no evidence of GRP gene expression. These data support the concept that SCLC which constitutively express the GRP gene and L-myc but not c-myc or N-myc can be stimulated in an autocrine fashion by GRP or its congeners to increase [Ca2+]i by a pathway involving phosphatidylinositol turnover.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
J B Trepel; J D Moyer; R Heikkila; E A SausvilleThe Biochemical journal 1988;255(2):403-10.
E A Sausville; J B Trepel; J D MoyerProgress in clinical and biological research 1990;354A():193-207.
M M Nau; B J Brooks; J Battey; E Sausville; A F Gazdar; I R Kirsch; O W McBride; V Bertness; G F Hollis; J D MinnaNature 1985;318(6041):69-73.
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