Purification and analysis of colonization factor antigen I, coli surface antigen 1, and coli surface antigen 3 fimbriae from enterotoxigenic Escherichia coli.

Publication Detail

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R H Hall; D R Maneval; J H Collins; J L Theibert; M M Levine (Profiled Author: Myron M Levine)

Department of Medicine, University of Maryland School of Medicine, Baltimore.
Journal of bacteriology 1989;171(11):6372-4.

PubMed

Abstract

Enterotoxigenic Escherichia coli fimbriae are immunogenic and play a key role in intestinal colonization. Native colonization factor antigen I, coli surface antigen 1, and coli surface antigen 3 fimbriae were purified by a common method involving shearing, differential centrifugation, gel filtration, and density gradient ultracentrifugation. The compositions and N-terminal sequences were determined. Coli surface antigen 3 possesses two N-terminal isoforms, one of which matches the published DNA sequence, except for the previously proposed signal sequence cleavage point.

3 Originating Grant

1.

LEVINE, MYRON M

STUDY OF MALARIA VACCINES IN HUMAN VOLUNTEERS
2.

LEVINE, MYRON M

FACILITY FOR STUDY OF INFECTIOUS DISEASES, VACCINES
3.

LEVINE, MYRON M

STUDY OF MALARIA VACCINES IN HUMAN VOLUNTEERS

Scientific Context

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