The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.
Intraarterial papaverine infusion for cerebral vasospasm after subarachnoid hemorrhage.
Department of Radiology, University of Maryland Medical System, Baltimore.
AJNR. American journal of neuroradiology 1995;16(1):27-38.
PURPOSE: To evaluate the techniques and efficacy of intracranial intraarterial papaverine infusion for symptomatic vasospasm after subarachnoid hemorrhage caused by aneurysm rupture. METHODS: Papaverine was infused on 19 occasions in 14 patients, 6 hours to 2 days after spasm became apparent clinically. Sixty vascular territories were treated. Infusion was made into the supraclinoid internal carotid artery 20 times, cavernous internal carotid artery once, selective A1 anterior cerebral artery 8 times, M1 middle cerebral artery 7 times, and basilar artery 3 times. Papaverine doses ranged from 150 to 600 mg and exceeded 400 mg on 8 occasions. RESULTS: Angiographic improvement occurred in 18 (95%) of the 19 treatment sessions: results were excellent in 3 sessions, moderate in 8, and mild in 7. The best angiographic results often were obtained with superselective infusion, although angiographic results did not always correlate with clinical response. Seven (50%) of the 14 treated patients showed dramatic acute clinical improvement within 24 hours of papaverine therapy, and there was no clinical evidence of recurrent vasospasm in these patients. Recurrence of angiographic vasoconstriction was demonstrated in three patients; one showed marked clinical improvement after a second treatment. There were no episodes of systemic hypotension in any of the cases. Monocular blindness developed in one patient because of papaverine infusion near the ophthalmic artery. CONCLUSIONS: Papaverine was effective in dilating narrowed arteries in most patients with symptomatic vasospasm caused by subarachnoid hemorrhage. This series showed encouraging clinical results with no recurrence of neurologic deterioration in those patients who responded well to papaverine. Superselective infusion appears to be indicated in some cases for adequate papaverine delivery.
This section shows information related to the publication - computed using the fingerprint of the publication - including related publications, related experts and related grants with fingerprints representing significant amounts of overlap between their fingerprint and this publication. The red dots indicate whether those experts or terms appear within the publication, thereby showing potential and actual connections.
M A Wozniak; M A Sloan; M I Rothman; C M Burch; D Rigamonti; T Permutt; Y NumaguchiJournal of neuroimaging : official journal of the American Society of Neuroimaging 1996;6(2):87-93.
Y Numaguchi; G H Zoarski; J E Clouston; M T Zagardo; J M Simard; E F Aldrich; M A Sloan; P K Maurer; S H OkawaraNeuroradiology 1997;39(10):751-9.
C M Burch; M A Wozniak; M A Sloan; M I Rothman; D Rigamonti; T Permutt; Y NumaguchiJournal of neuroimaging : official journal of the American Society of Neuroimaging 1996;6(1):8-15.
Appears in this Publication
Author of this Publication