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Marcela F Pasetti

Publication Detail

The publication detail shows the title, authors (with indicators showing other profiled authors), information on the publishing organization, abstract and a link to the article in PubMed. This abstract is what is used to create the fingerprint of the publication. If any grants are referenced by the publication, they will be listed here as well.



Vibrio cholerae O1 can assume a chlorine-resistant rugose survival form that is virulent for humans.

J G Morris; M B Sztein; E W Rice; J P Nataro; G A Losonsky; P Panigrahi; C O Tacket; J A Johnson (Profiled Author: Marcelo B Sztein)

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, USA.
The Journal of infectious diseases 1996;174(6):1364-8.

Abstract

Vibrio cholerae can shift to a "rugose" colonial morphology associated with expression of an amorphous exopolysaccharide that promotes cell aggregation. Flow cytometric studies indicated that up to 3% of particles in rugose cultures represented aggregates of >5 bacterial cells. Rugose variants of our test strains displayed resistance to killing by chlorine, with viable cells persisting for >30 min in 2 mg/L free chlorine; strains also showed resistance to killing by complement-mediated serum bactericidal activity. Six volunteers fed 10(6) cfu of a rugose variant of V. cholerae O1 El Tor Inaba N16961 developed symptoms typical of cholera, with a mean diarrheal stool volume of 2.2 L (range, 1.4-4.3). Isolates recovered from the stool of infected volunteers retained the rugose phenotype. The data suggest that rugose strains cause human disease. The role of these strains in the epidemiology of cholera remains to be determined.

11 Originating Grant

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